An imidazopyridine is a nitrogen containing
heterocycle that is also a class of
drugs that contain this same chemical substructure. In general, they are
GABAA receptoragonists, however recently
proton pump inhibitors,
aromatase inhibitors,
NSAIDs and other classes of drugs in this class have been developed as well. Despite usually being similar to them in effect, they are not chemically related to benzodiazepines. As such, GABAA-agonizing imidazopyridines,
pyrazolopyrimidines, and
cyclopyrrones are sometimes grouped together and referred to as "
nonbenzodiazepines." Imidazopyridines include:
TP-003—a subtype-selective
partial agonist at
GABAA receptors, binding to GABAA receptor complexes bearing either
α2,
α3 or
α5 subunits, but only showing significant efficacy at α3.
Zolpidem (original brand name Ambien)—a widely used
hypnotic. Generic versions are widely available.
SCH28080—the prototypical potassium-competitive acid blocker which has not found clinical use because of liver toxicity in animal trials and elevated liver enzyme activity in the serum of human volunteers.[7]
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