Several
water-soluble derivatives and
prodrugs of the widely used intravenous anesthetic agent
propofol have been developed, of which fospropofol has been found to be the most suitable for clinical development thus far.[5][6] Purported advantages of this water-soluble
chemical compound include less pain at the site of intravenous administration, less potential for
hyperlipidemia with long-term administration, and less chance for
bacteremia.[citation needed] Often, fospropofol is administered in conjunction with an opioid such as fentanyl.[citation needed]
^Cooke A, Anderson A, Buchanan K, Byford A, Gemmell D, Hamilton N, et al. (April 2001). "Water-soluble propofol analogues with intravenous anaesthetic activity". Bioorganic & Medicinal Chemistry Letters. 11 (7): 927–930.
doi:
10.1016/S0960-894X(01)00088-9.
PMID11294393.
^Bennett DJ, Anderson A, Buchanan K, Byford A, Cooke A, Gemmell DK, et al. (June 2003). "Novel water soluble 2,6-dimethoxyphenyl ester derivatives with intravenous anaesthetic activity". Bioorganic & Medicinal Chemistry Letters. 13 (12): 1971–1975.
doi:
10.1016/S0960-894X(03)00346-9.
PMID12781176.