Valofane is a
sedative drug structurally related to the
barbiturates[1] and similar drugs such as
primidone. It is metabolized once inside the body to form the barbiturate
proxibarbital (proxibarbal) and is thus a
prodrug.[2]
References
^Traversa U, Puppini P, Jacquot C, Vertua R (1985). "Effect of an atypical barbiturate, the 2-allophanyl-2-allyl-4-valerolactone (valofan), on exploratory behaviour and brain serotonin concentrations in mice". Journal de Pharmacologie. 16 (3): 279–90.
PMID2415778.
^Lambrey B, Compagnon PL, Jacquot C (1981). "Pharmacokinetics of 14C-2-allophanyl-2-allyl -gamma-valero-lactone: a prodrug of proxibarbal in rats". European Journal of Drug Metabolism and Pharmacokinetics. 6 (3): 161–9.
doi:
10.1007/BF03189485.
PMID6118275.
S2CID10197120.