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Fludiazepam
Clinical data
Trade namesErispan ( JP, TW)
AHFS/ Drugs.com International Drug Names
Routes of
administration		Oral ( tablets)
Drug class Benzodiazepine
ATC code
Legal status
Legal status
Pharmacokinetic data
Metabolism Hepatic
Excretion Renal
Identifiers
  • 7-chloro-5-(2-fluorophenyl)-1-methyl-1,3-dihydro-2H-1,4-benzodiazepin-2-one
CAS Number
PubChem CID
DrugBank
ChemSpider
UNII
KEGG
ChEBI
ChEMBL
CompTox Dashboard ( EPA)
ECHA InfoCard 100.292.343 Edit this at Wikidata
Chemical and physical data
FormulaC16H12ClFN2O
Molar mass302.73 g·mol−1
3D model ( JSmol)
  • O=C1CN=C(C2=CC=CC=C2F)C3=CC(Cl)=CC=C3N1C
  • InChI=1S/C16H12ClFN2O/c1-20-14-7-6-10(17)8-12(14)16(19-9-15(20)21)11-4-2-3-5-13(11)18/h2-8H,9H2,1H3 checkY
  • Key:ROYOYTLGDLIGBX-UHFFFAOYSA-N checkY
   (verify)

Fludiazepam, [2] marketed under the brand name Erispan (エリスパン) [3] [4] is a potent benzodiazepine and 2ʹ-fluoro derivative of diazepam, [5] originally developed by Hoffmann-La Roche in the 1960s. [6] It is marketed in Japan and Taiwan. [ citation needed] It exerts its pharmacological properties via enhancement of GABAergic inhibition. [7] Fludiazepam has 4 times more binding affinity for benzodiazepine receptors than diazepam. [8] It possesses anxiolytic, [9] [10] [11] anticonvulsant, sedative, hypnotic and skeletal muscle relaxant properties. [12] Fludiazepam has been used recreationally. [13]

See also

References

  1. ^ Anvisa (2023-03-31). "RDC Nº 784 - Listas de Substâncias Entorpecentes, Psicotrópicas, Precursoras e Outras sob Controle Especial" [Collegiate Board Resolution No. 784 - Lists of Narcotic, Psychotropic, Precursor, and Other Substances under Special Control] (in Brazilian Portuguese). Diário Oficial da União (published 2023-04-04). Archived from the original on 2023-08-03. Retrieved 2023-08-16.
  2. ^ US Patent 3371085 5-aryl-3h-1,4-benzodiazepin-2(1h)-ones
  3. ^ Su TP, Chen TJ, Hwang SJ, Chou LF, Fan AP, Chen YC (August 2002). "Utilization of psychotropic drugs in Taiwan: an overview of outpatient sector in 2000". Zhonghua Yi Xue Za Zhi (Chinese Medical Journal; Free China Ed). 65 (8): 378–91. PMID  12455808.
  4. ^ "Benzodiazepine Names". non-benzodiazepines.org.uk. Archived from the original on 2008-12-08. Retrieved 2008-12-29.
  5. ^ Neville GA, Beckstead HD, Shurvell HF (February 1994). "A Fourier transform-Raman and infrared vibrational study of delorazepam, fludiazepam, flurazepam, and tetrazepam". Journal of Pharmaceutical Sciences. 83 (2): 143–51. doi: 10.1002/jps.2600830207. PMID  7909552.
  6. ^ US Patent 3299053 -ARYL-JH-L,X-BENZODIAZEPIN-Z(LH)-ONES
  7. ^ Tsuchiya T, Fukushima H (April 1978). "Effects of benzodiazepines and pentobarbitone on the gaba-ergic recurrent inhibition of hippocampal neurons". European Journal of Pharmacology. 48 (4): 421–4. doi: 10.1016/0014-2999(78)90169-3. PMID  648585.
  8. ^ Nakatsuka I, Shimizu H, Asami Y, Katoh T, Hirose A, Yoshitake A (January 1985). "Benzodiazepines and their metabolites: relationship between binding affinity to the benzodiazepine receptor and pharmacological activity". Life Sciences. 36 (2): 113–9. doi: 10.1016/0024-3205(85)90089-X. PMID  2857046.
  9. ^ Okada S, Ichiki K, Tanokuchi S, Ishii K, Hamada H, Ota Z (1994). "Effect of an anxiolytic on lipid profile in non-insulin-dependent diabetes mellitus". The Journal of International Medical Research. 22 (6): 338–42. doi: 10.1177/030006059402200605. PMID  7895897. S2CID  9591519.
  10. ^ Okada S, Ichiki K, Tanokuchi S, Ishii K, Hamada H, Ota Z (1995). "Improvement of stress reduces glycosylated haemoglobin levels in patients with type 2 diabetes". The Journal of International Medical Research. 23 (2): 119–22. doi: 10.1177/030006059502300205. PMID  7601294. S2CID  12865838.
  11. ^ Okada S, Ichiki K, Tanokuchi S, Ishii K, Hamada H, Ota Z (1995). "How blood pressure in patients with non-insulin-dependent diabetes mellitus is influenced by stress". The Journal of International Medical Research. 23 (5): 377–80. doi: 10.1177/030006059502300508. PMID  8529781. S2CID  42485678.
  12. ^ Inoue H, Maeno Y, Iwasa M, Matoba R, Nagao M (September 2000). "Screening and determination of benzodiazepines in whole blood using solid-phase extraction and gas chromatography/mass spectrometry". Forensic Science International. 113 (1–3): 367–73. doi: 10.1016/S0379-0738(00)00226-7. PMID  10978650.
  13. ^ Shimamine M, Masunari T, Nakahara Y (1993). "[Studies on identification of drugs of abuse by diode array detection. I. Screening-test and identification of benzodiazepines by HPLC-DAD with ICOS software system]". Eisei Shikenjo Hokoku. Bulletin of National Institute of Hygienic Sciences (111): 47–56. PMID  7920567.

External links

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