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Chemical compound
3-MeO-PCE
Other names 3-MeO-PCE; Methoxieticyclidine
Legal status
DE :
NpSG (Industrial and scientific use only)
UK :
Class B
Illegal in Sweden and Switzerland
N -Ethyl-1-(3-methoxyphenyl)cyclohexan-1-amine
CAS Number
PubChem
CID
ChemSpider
UNII
Formula C 15 H 23 N O
Molar mass 233.355 g·mol−1 3D model (
JSmol )
CCNC1(CCCCC1)C2=CC(=CC=C2)OC
InChI=1S/C15H23NO/c1-3-16-15(10-5-4-6-11-15)13-8-7-9-14(12-13)17-2/h7-9,12,16H,3-6,10-11H2,1-2H3
Key:OFGOOZLOGUNDFS-UHFFFAOYSA-N
3-Methoxyeticyclidine (3-MeO-PCE ), also known as methoxieticyclidine ,
[1] is a
dissociative
anesthetic that is qualitatively similar to
PCE and
PCP
[1] and has been sold online as a
designer drug .
[2]
[3]
[4]
On October 18, 2012, the
Advisory Council on the Misuse of Drugs in the
United Kingdom released a report about
methoxetamine , saying that the "harms of methoxetamine are commensurate with
Class B of the
Misuse of Drugs Act (1971) ", despite the fact that the act does not classify drugs based on harm. The report went on to suggest that all analogues of methoxetamine should also become class B drugs and suggested a catch-all clause covering both existing and unresearched arylcyclohexamines, including 3-MeO-PCE.
[5]
This report also described the receptor binding profile of methoxetamine and three additional dissociatives
3-MeO-PCP ,
4-MeO-PCP , and 3-MeO-PCE, showing them to have significant affinity for the PCP site of the
NMDA receptor (NMDAR) and was later published in more detail.
[6]
3-MeO-PCE has
Ki values of 61 nM for the NMDAR, 743 nM for the
dopamine transporter , 2097 nM for the
histamine H2 receptor , 964 nM for the
alpha-2A adrenergic receptor , 115 nM for the
serotonin transporter , 4519 nM for the
σ1 receptor , and 525 nM for the
σ2 receptor .
[6]
Legal status
3-MeO-PCE is banned in Sweden
[7]
[8] and Switzerland.
[9]
As per Chile's
Ley de drogas , aka Ley 20000,
[10] all esters and ethers of PCE are illegal. As 3-MeO-PCE is an
ether of PCE, it is thus illegal.
See also
References
^
a
b Morris H, Wallach J (July–August 2014). "From PCP to MXE: a comprehensive review of the non-medical use of dissociative drugs". Drug Testing and Analysis . 6 (7–8): 614–32.
doi :
10.1002/dta.1620 .
PMID
24678061 .
^ De Paoli G, Brandt SD, Wallach J, Archer RP, Pounder DJ (June 2013).
"From the street to the laboratory: analytical profiles of methoxetamine, 3-methoxyeticyclidine and 3-methoxyphencyclidine and their determination in three biological matrices" . Journal of Analytical Toxicology . 37 (5): 277–83.
doi :
10.1093/jat/bkt023 .
PMID
23552616 .
^ Wallach J, Colestock T, Cicali B, Elliott SP, Kavanagh PV, Adejare A, et al. (August 2016).
"Syntheses and analytical characterizations of N-alkyl-arylcyclohexylamines" (PDF) . Drug Testing and Analysis . 8 (8): 801–15.
doi :
10.1002/dta.1861 .
PMID
26360516 .
S2CID
1599386 .
^
"3-MeO-PCE" . New Synthetic Drugs Database . Archived from
the original on 2016-07-29. Retrieved 2016-08-27 .
^
"Advisory Council on the Misuse of Drugs (ACMD) Methoxetamine report, 2012" . UK Home Office . 18 October 2012.
^
a
b
Roth BL , Gibbons S, Arunotayanun W, Huang XP, Setola V, Treble R, Iversen L (March 2013).
"The ketamine analogue methoxetamine and 3- and 4-methoxy analogues of phencyclidine are high affinity and selective ligands for the glutamate NMDA receptor" . PLOS ONE . 8 (3): e59334.
Bibcode :
2013PLoSO...859334R .
doi :
10.1371/journal.pone.0059334 .
PMC
3602154 .
PMID
23527166 .
^
"Elva nya ämnen klassas som narkotika eller hälsofarlig vara" (in Swedish). Folkhälsomyndigheten. 28 June 2018.
^ Riksdagsförvaltningen.
"Förordning (1992:1554) om kontroll av narkotika" . riksdagen.se (in Swedish).
^
"Verordnung des EDI vom 30. Mai 2011 über die Verzeichnisse der Betäubungsmittel, psychotropen Stoffe, Vorläuferstoffe und Hilfschemikalien (Betäubungsmittelverzeichnisverordnung, BetmVV-EDI)" (in German). Der Bundesrat.
^
"SUSTITUYE LA LEY Nº 19.366, QUE SANCIONA EL TRAFICO ILICITO DE ESTUPEFACIENTES Y SUSTANCIAS SICOTROPICAS" (in Spanish). Bibloteca Del Congreso Nacional. 22 October 2015. Retrieved 6 February 2018 .
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