From Wikipedia, the free encyclopedia
Chemical compound
MN 18 is an
indazole -based
synthetic cannabinoid that is an
agonist for the
cannabinoid receptors , with
K i values of 45.72 nM at
CB1 and 11.098 nM at
CB2 and
EC50 values of 2.028 nM at CB1 and 1.233 nM at CB2 ,
[1] and has been sold online as a
designer drug .
[2]
[3] It is the indazole core analogue of
NNE1 . Given the known metabolic liberation (and presence as an impurity) of
amantadine in the related compound
APINACA , it is suspected that metabolic hydrolysis of the amide group of MN-18 may release
1-naphthylamine , a known
carcinogen . MN-18 metabolism has been described in literature.
[4]
[5]
Legal status
MN-18 is banned in Sweden.[
when? ]
[6]
On 15 September 2014 the Turkey government banned the sale of MN-18.
[7]
See also
References
^ Gamage TF, Farquhar CE, Lefever TW, Marusich JA, Kevin RC, McGregor IS, et al. (May 2018).
"Molecular and Behavioral Pharmacological Characterization of Abused Synthetic Cannabinoids MMB- and MDMB-FUBINACA, MN-18, NNEI, CUMYL-PICA, and 5-Fluoro-CUMYL-PICA" . The Journal of Pharmacology and Experimental Therapeutics . 365 (2): 437–446.
doi :
10.1124/jpet.117.246983 .
PMC
5932312 .
PMID
29549157 .
^
"MN-18" . Southern Association of Forensic Scientists. Archived from
the original on 23 July 2015. Retrieved 23 July 2015 .
^ Uchiyama N, Shimokawa Y, Kikura-Hanajiri R, Demizu Y, Goda Y, Hakamatsuka T (February 2015).
"N-OH-EDMA, and a cathinone derivative dimethoxy-α-PHP, newly identified in illegal products" . Forensic Toxicology . 33 (2): 244–259.
doi :
10.1007/s11419-015-0268-7 .
PMC
4525202 .
PMID
26257833 .
^ Diao X, Carlier J, Zhu M, Huestis MA (November 2017).
"Human Hepatocyte Metabolism of Novel Synthetic Cannabinoids MN-18 and Its 5-Fluoro Analog 5F-MN-18" . Clinical Chemistry . 63 (11): 1753–1763.
doi :
10.1373/clinchem.2017.277152 .
PMID
28821542 .
^ Kevin RC, Lefever TW, Snyder RW, Patel PR, Gamage TF, Fennell TR, et al. (January 2018).
"Kinetic and metabolic profiles of synthetic cannabinoids NNEI and MN-18" . Drug Testing and Analysis . 10 (1): 137–147.
doi :
10.1002/dta.2262 .
PMC
5785468 .
PMID
28834241 .
^
"Cannabinoider föreslås bli klassificerade som hälsofarlig vara" . Folkhälsomyndigheten. 28 May 2014. Retrieved 23 July 2015 .
^
"Turkish Drug Law List" . Resmi Gazete. 15 Sep 2014.
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