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CompTox Dashboard ( EPA) | |
ECHA InfoCard | 100.021.825 |
Chemical and physical data | |
Formula | C20H27NO |
Molar mass | 297.442 g·mol−1 |
3D model ( JSmol) | |
Density | 1.19 g/cm3 |
Melting point | 188 °C (370 °F) |
Boiling point | 458.4 °C (857.1 °F) |
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Cyclorphan is an opioid analgesic of the morphinan family that was never marketed. [1] It acts as a μ-opioid receptor (MOR) weak partial agonist or antagonist, κ-opioid receptor (KOR) full agonist, and, to a much lesser extent, δ-opioid receptor (DOR) agonist (75-fold lower affinity relative to the KOR). [2] [3] The drug was first synthesized in 1964 by scientists at Research Corporation. [4] [5]: 232 In clinical trials, it had relatively long duration, good absorption, and provided strong pain relief but produced psychotomimetic effects via KOR activation, so its development was not continued. [1] [5]: 232, 237
Psychedelics ( 5-HT2A agonists) |
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Dissociatives ( NMDAR antagonists) |
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Deliriants ( mAChR antagonists) |
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Others |
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μ-opioid (MOR) |
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δ-opioid (DOR) |
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κ-opioid (KOR) |
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Nociceptin (NOP) |
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Others |
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