From Wikipedia, the free encyclopedia
Chemical compound
PRE-084 is a
sigma receptor
agonist , selective for the
σ1 subtype. It has
nootropic and
antidepressant actions in animal studies, as well as
antitussive and reinforcing effects.
[1]
[2]
[3]
[4]
[5] PRE-084 increases the expression of
GDNF .
[6]
References
^ Maurice T, Su TP, Parish DW, Nabeshima T, Privat A (December 1994).
"PRE-084, a sigma selective PCP derivative, attenuates MK-801-induced impairment of learning in mice" . Pharmacology Biochemistry and Behavior . 49 (4): 859–69.
doi :
10.1016/0091-3057(94)90235-6 .
PMID
7886099 .
S2CID
54306053 .
^ Maurice T (November 2001). "Beneficial effect of the sigma(1) receptor agonist PRE-084 against the spatial learning deficits in aged rats". European Journal of Pharmacology . 431 (2): 223–7.
doi :
10.1016/S0014-2999(01)01436-4 .
PMID
11728429 .
^ Brown C, Fezoui M, Selig WM, Schwartz CE, Ellis JL (January 2004).
"Antitussive activity of sigma-1 receptor agonists in the guinea-pig" .
British Journal of Pharmacology . 141 (2): 233–40.
doi :
10.1038/sj.bjp.0705605 .
PMC
1574192 .
PMID
14691051 .
^ Skuza G, Rogóz Z (2009). "Antidepressant-like effect of PRE-084, a selective sigma1 receptor agonist, in Albino Swiss and C57BL/6J mice". Pharmacological Reports . 61 (6): 1179–83.
doi :
10.1016/S1734-1140(09)70181-1 .
PMID
20081254 .
S2CID
96025873 .
^ Hiranita T, Soto PL, Tanda G, Katz JL (February 2010).
"Reinforcing effects of sigma-receptor agonists in rats trained to self-administer cocaine" . The Journal of Pharmacology and Experimental Therapeutics . 332 (2): 515–24.
doi :
10.1124/jpet.109.159236 .
PMC
2812106 .
PMID
19892920 .
^ Penas C, Pascual-Font A, Mancuso R, Forés J, Casas C, Navarro X (May 2011). "Sigma receptor agonist 2-(4-morpholinethyl)1 phenylcyclohexanecarboxylate (Pre084) increases GDNF and BiP expression and promotes neuroprotection after root avulsion injury". J. Neurotrauma . 28 (5): 831–40.
doi :
10.1089/neu.2010.1674 .
PMID
21332255 .