Aeruginascin or N,N,N-trimethyl-4-phosphoryloxytryptamine is an
indoleamine derivative which occurs naturally within the mushrooms Inocybe aeruginascens[1][2][3][4][5][6] and Pholiotina cyanopus,[6] and Psilocybe cubensis.[7] Aeruginascin is the N-tri
methylanalogue of
psilocybin. It is closely related to the frog skin toxin
bufotenidine (5-HTQ), a potent
5-HT3 receptor agonist, but the aeruginascin metabolite 4-HO-TMT shows strong binding at the
5-HT2 receptors similar to
psilocin.[8][9] The first scientific literature about the pharmacological effects of aeruginascin is from a study published by Gartz in 1989.[10] Across 23 analyzed cases of accidental hallucinogenic mushroom poisonings, people who had ingested the mushroom Inocybe aeruginascens reported only euphoric experiences.[11] This is in contrast to the slight and in some cases extremely dysphoric experiences reported from the accidental ingestion of non aeruginascin containing mushrooms (containing solely psilocybin and psilocin).
References
^Gartz J (1995).
"Inocybe aeruginascens Babos". Eleusis, Journal of Psychoactive Plants & Compounds. 3. Museo Civico di Rovereto: 31–4.
^Sherwood AM, Halberstadt AL, Klein AK, McCorvy JD, Kaylo KW, Kargbo RB, Meisenheimer P (February 2020). "Synthesis and Biological Evaluation of Tryptamines Found in Hallucinogenic Mushrooms: Norbaeocystin, Baeocystin, Norpsilocin, and Aeruginascin". Journal of Natural Products. 83 (2): 461–467.
doi:
10.1021/acs.jnatprod.9b01061.
PMID32077284.
S2CID211214973.
^Servillo L, Giovane A, Balestrieri ML, Cautela D, Castaldo D (September 2012). "N-methylated tryptamine derivatives in citrus genus plants: identification of N,N,N-trimethyltryptamine in bergamot". Journal of Agricultural and Food Chemistry. 60 (37): 9512–9518.
doi:
10.1021/jf302767e.
PMID22957740.