AM-694 (1-(5-fluoropentyl)-3-(2-iodobenzoyl)indole) is a
designer drug that acts as a potent and selective
agonist for the
cannabinoid receptorCB1. It is used in scientific research for mapping the distribution of CB1 receptors.[1]
Pharmacology
AM-694 is an
agonist for
cannabinoid receptors. It has a
Ki of 0.08 nM at
CB1 and 18 times selectivity over
CB2 with a Ki of 1.44 nM.[2] It is unclear what is responsible for this unusually high CB1 binding affinity, but it makes the
18Fradiolabelled derivative of AM-694 useful for mapping the distribution of CB1 receptors in the body.[1]
^Grigoryev A, Kavanagh P, Melnik A (February 2013). "The detection of the urinary metabolites of 1-[(5-fluoropentyl)-1H-indol-3-yl]-(2-iodophenyl)methanone (AM-694), a high affinity cannabimimetic, by gas chromatography - mass spectrometry". Drug Testing and Analysis. 5 (2): 110–5.
doi:
10.1002/dta.1336.
PMID22522907.
^Apirakkan O, Gavrilović I, Cowan DA, Abbate V (July 2020). "In Vitro Phase I Metabolic Profiling of the Synthetic Cannabinoids AM-694, 5F-NNEI, FUB-APINACA, MFUBINAC, and AMB-FUBINACA". Chemical Research in Toxicology. 33 (7): 1653–1664.
doi:
10.1021/acs.chemrestox.9b00466.
PMID32301604.
S2CID215803607.