JWH-302 (1-pentyl-3-(3-methoxyphenylacetyl)indole) is an
analgesic chemical from the
phenylacetylindole family, which acts as a
cannabinoidagonist with moderate affinity at both the
CB1 and
CB2 receptors. It is a
positional isomer of the more common drug
JWH-250, though it is slightly less potent with a
Ki of 17 nM at CB1, compared to 11 nM for JWH-250.[1][2] Because of their identical
molecular weight and similar fragmentation patterns, JWH-302 and JWH-250 can be very difficult to distinguish by
GC-MS testing.[3]
^Huffman JW, Szklennik PV, Almond A, Bushell K, Selley DE, He H, et al. (September 2005). "1-Pentyl-3-phenylacetylindoles, a new class of cannabimimetic indoles". Bioorganic & Medicinal Chemistry Letters. 15 (18): 4110–3.
doi:
10.1016/j.bmcl.2005.06.008.
PMID16005223.
^Manera C, Tuccinardi T, Martinelli A (April 2008). "Indoles and related compounds as cannabinoid ligands". Mini Reviews in Medicinal Chemistry. 8 (4): 370–87.
doi:
10.2174/138955708783955935.
PMID18473928.