Dexoxadrol (Dioxadrol) is a
dissociativeanaesthetic drug which has been found to be an
NMDA antagonist and produces similar effects to
PCP in animals. Dexoxadrol, along with another related drug
etoxadrol, were developed as
analgesics for use in humans, but development was discontinued after patients reported side effects such as
nightmares and
hallucinations.[1][2]
^Sax M, Wünsch B (2006). "Relationships between the structure of dexoxadrol and etoxadrol analogues and their NMDA receptor affinity". Current Topics in Medicinal Chemistry. 6 (7): 723–32.
doi:
10.2174/156802606776894483.
PMID16719812.
^Aepkers M, Wünsch B (December 2005). "Structure-affinity relationship studies of non-competitive NMDA receptor antagonists derived from dexoxadrol and etoxadrol". Bioorganic & Medicinal Chemistry. 13 (24): 6836–49.
doi:
10.1016/j.bmc.2005.07.030.
PMID16169732.