From Wikipedia, the free encyclopedia
Chemical compound
PX-2
Legal status
(S )-N -(1-amino-1-oxo-3-phenylpropan-2-yl)-1-(5-fluoropentyl)-1H -indazole-3-carboxamide
CAS Number
ChemSpider
UNII
Formula C 22 H 25 F N 4 O 2
Molar mass 396.466 g·mol−1 3D model (
JSmol )
O=C(N[C@@H](C(N)=O)CC1=CC=CC=C1)C2=NN(CCCCCF)C3=C2C=CC=C3
InChI=1S/C22H25FN4O2/c23-13-7-2-8-14-27-19-12-6-5-11-17(19)20(26-27)22(29)25-18(21(24)28)15-16-9-3-1-4-10-16/h1,3-6,9-12,18H,2,7-8,13-15H2,(H2,24,28)(H,25,29)/t18-/m1/s1
Key:OJTAHWMZBJRSIR-GOSISDBHSA-N
PX-2 (also known as 5F-APP-PINACA , FU-PX and PPA(N)-2201 ) is an
indazole -based
synthetic cannabinoid that has been sold online as a
designer drug .
[1]
[2]
[3] It contains a
phenylalanine amino acid amide as part of its structure.
Legality
Sweden's public health agency suggested classifying PX-2 as hazardous substance on November 10, 2014.
[4]
PX-2 is listed in the Fifth Schedule of the Misuse of Drugs Act (MDA) and therefore illegal in Singapore as of May 2015.
[5]
As of October 2015 PX-2 is a controlled substance in China.
[6]
See also
References
^
"PX 2" . Cayman Chemical. Retrieved 15 July 2015 .
^ Qian Z, Jia W, Li T, Hua Z, Liu C (January 2017). "Identification and analytical characterization of four synthetic cannabinoids ADB-BICA, NNL-1, NNL-2, and PPA(N)-2201". Drug Testing and Analysis . 9 (1): 51–60.
doi :
10.1002/dta.1990 .
PMID
27239006 .
^ Dahm P, Thomas A, Rothschild MA, Thevis M, Mercer-Chalmers-Bender K (July 2022).
"Phase I-metabolism studies of the synthetic cannabinoids PX-1 and PX-2 using three different in vitro models" . Forensic Toxicology . 40 (2): 244–262.
doi :
10.1007/s11419-021-00606-6 .
PMC
9715525 .
PMID
36454402 .
S2CID
245540105 .
^
"Cannabinoider föreslås bli klassade som hälsofarlig vara" [Cannabinoids are proposed to be classified as dangerous to health]. Folkhälsomyndigheten. Retrieved 16 July 2015 .
^
"CNB NEWS RELEASE" . Central Narcotics Bureau (CNB). 30 April 2015. Archived from
the original on 15 July 2015. Retrieved 24 July 2015 .
^
"关于印发《非药用类麻醉药品和精神药品列管办法》的通知" [On the issuance of non-pharmaceutical narcotic drugs and psychotropic substances listed in the notice] (in Chinese). China Food and Drug Administration. 27 September 2015. Archived from
the original on 1 October 2015. Retrieved 1 October 2015 .
Phytocannabinoids (
comparison )
Cannabibutols Cannabichromenes Cannabicyclols Cannabidiols Cannabielsoins Cannabigerols Cannabiphorols Cannabinols Cannabitriols Cannabivarins Delta-8-tetrahydrocannabinols Delta-9-tetrahydrocannabinols Delta-10-Tetrahydrocannabinols Miscellaneous cannabinoids Active metabolites
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Classical cannabinoids (dibenzopyrans) Non-classical cannabinoids Adamantoylindoles Benzimidazoles Benzoylindoles Cyclohexylphenols
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Hydrocarbons Indazole carboxamides Indazole-3- carboxamides Indole-3-carboxamides Indole-3-carboxylates Naphthoylindazoles
Naphthoylindoles Naphthoylpyrroles Naphthylmethylindenes Naphthylmethylindoles Phenylacetylindoles Pyrazolecarboxamides Pyrrolobenzoxazines Quinolinyl esters Tetramethylcyclo- propanoylindazoles Tetramethylcyclo- propanoylindoles Tetramethylcyclo- propylindoles Others
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A-796,260
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Transporter (
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Enzyme (
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Others
Others:
2-PG (directly potentiates activity of 2-AG at CB1 receptor)
ARN-272 (FAAH-like anandamide transporter inhibitor)