From Wikipedia, the free encyclopedia
Chemical compound
ZCZ-011
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6-methyl-3-(2-nitro-1-(thiophen-2-yl)ethyl)-2-phenyl-1H-indole
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CAS Number | |
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PubChem
CID | |
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IUPHAR/BPS | |
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ChemSpider | |
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PDB ligand | |
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Formula | C21H18N2O2S |
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Molar mass | 362.45 g·mol−1 |
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3D model (
JSmol) | |
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Cc1ccc2c([nH]c(c3ccccc3)c2C(C[N+]([O-])=O)c4sccc4)c1
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InChI=1S/C21H18N2O2S/c1-14-9-10-16-18(12-14)22-21(15-6-3-2-4-7-15)20(16)17(13-23(24)25)19-8-5-11-26-19/h2-12,17,22H,13H2,1H3 Key:RJSPNRDBWHHFMH-UHFFFAOYSA-N
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ZCZ-011 is a positive
allosteric modulator of the
cannabinoid
CB1
receptor.
[1]
[2]
See also
References
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^ Poklis JL, Clay DJ, Ignatowska-Jankowska BM, Zanato C, Ross RA, Greig IR, et al. (June 2015).
"HPLC-MS-MS Determination of ZCZ-011, A Novel Pharmacological Tool for Investigation of the Cannabinoid Receptor in Mouse Brain Using Clean Screen FASt™ Column Extraction". Journal of Analytical Toxicology. 39 (5): 353–8.
doi:
10.1093/jat/bkv015.
PMC
4542657.
PMID
25737338.
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^ Ignatowska-Jankowska BM, Baillie GL, Kinsey S, Crowe M, Ghosh S, Owens RA, et al. (December 2015).
"A Cannabinoid CB1 Receptor-Positive Allosteric Modulator Reduces Neuropathic Pain in the Mouse with No Psychoactive Effects". Neuropsychopharmacology. 40 (13): 2948–59.
doi:
10.1038/npp.2015.148.
PMC
4864630.
PMID
26052038.
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Phytocannabinoids (
comparison) | Cannabibutols | |
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Cannabichromenes | |
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Cannabicyclols | |
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Cannabidiols | |
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Cannabielsoins | |
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Cannabigerols | |
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Cannabiphorols | |
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Cannabinols | |
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Cannabitriols | |
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Cannabivarins | |
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Delta-8-tetrahydrocannabinols | |
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Delta-9-tetrahydrocannabinols | |
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Delta-10-Tetrahydrocannabinols | |
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Miscellaneous cannabinoids | |
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Active metabolites | |
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Endocannabinoids | |
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Synthetic cannabinoid receptor agonists / neocannabinoids | Classical cannabinoids (dibenzopyrans) | |
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Non-classical cannabinoids | |
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Adamantoylindoles | |
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Benzimidazoles | |
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Benzoylindoles | |
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Cyclohexylphenols | |
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Eicosanoids | |
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Hydrocarbons | |
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Indazole carboxamides | |
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Indazole-3- carboxamides | |
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Indole-3-carboxamides | |
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Indole-3-carboxylates | |
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Naphthoylindazoles | |
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Naphthoylindoles | |
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Naphthoylpyrroles | |
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Naphthylmethylindenes | |
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Naphthylmethylindoles | |
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Phenylacetylindoles | |
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Pyrazolecarboxamides | |
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Pyrrolobenzoxazines | |
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Quinolinyl esters | |
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Tetramethylcyclo- propanoylindazoles | |
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Tetramethylcyclo- propanoylindoles | |
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Tetramethylcyclo- propylindoles | |
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Others | |
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Allosteric
CBRTooltip Cannabinoid receptor
ligands | |
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Endocannabinoid enhancers (inactivation inhibitors) | |
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Anticannabinoids (antagonists/inverse agonists/antibodies) | |
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Receptor (
ligands) |
CB1Tooltip Cannabinoid receptor type 1 | Agonists (abridged,
full list) | |
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Inverse agonists | |
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Antagonists | |
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CB2Tooltip Cannabinoid receptor type 2 | Agonists |
-
2-AG
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2-AGE (noladin ether)
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3,3'-Diindolylmethane
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4-O-Methylhonokiol
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α-Amyrin · β-Amyrin
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A-796,260
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A-834,735
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A-836,339
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AM-1172
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AM-1221
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AM-1235
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AM-1241
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AM-2232
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Anandamide
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AZ-11713908
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Cannabinol
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Caryophyllene
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CB-13
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CBS-0550
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CP 55,940
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GW-405,833 (L-768,242)
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GW-842,166X
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HU-308
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JTE 7-31
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JWH-007
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JWH-015
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JWH-018
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JWH-73
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JWH-133
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L-759,633
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L-759,656
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Lenabasum (anabasum)
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Magnolol
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MDA-19
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Nabitan
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NADA
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Olorinab (APD-371)
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PF-03550096
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S-444,823
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SER-601
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Serinolamide A
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UR-144
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Tedalinab
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THC (dronabinol)
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THCV
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Tetrahydromagnolol
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Virodhamine
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Antagonists | |
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NAGly (
GPR18) | |
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GPR55 | |
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GPR119 | |
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Transporter (
modulators) |
eCBTsTooltip Endocannabinoid transporter | |
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Enzyme (
modulators) | |
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Others |
- Others:
2-PG (directly potentiates activity of 2-AG at CB1 receptor)
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ARN-272 (FAAH-like anandamide transporter inhibitor)
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