Adamantyl-THPINACA (ATHPINACA, AD-THPINACA)[1] is an
indazole-based
synthetic cannabinoid,[2] which was first reported to
Europol in Slovenia in January 2015.[3] It is known as both the 1-adamantyl and 2-adamantyl isomers (SGT-40 and SGT-194 respectively), which can be distinguished by
GC-EI-MS.[4] It is banned in Sweden[5] and
Russia.[6] Both the 1-adamantyl and 2-adamantyl isomers are specifically listed as illegal drugs in Japan.[7] Given the known metabolic liberation (and presence as an impurity) of
amantadine in the related compound
APINACA, it is suspected that metabolic
hydrolysis of the amide group of Adamantyl-THPINACA may also release amantadine.
^Asada A, Doi T, Tagami T, Takeda A, Sawabe Y (March 2017). "Isomeric discrimination of synthetic cannabinoids by GC-EI-MS: 1-adamantyl and 2-adamantyl isomers of N-adamantyl carboxamides". Drug Testing and Analysis. 9 (3): 378–388.
doi:
10.1002/dta.2124.
PMID27770510.