From Wikipedia, the free encyclopedia
Chemical compound
O-1238
(6aR )-3-[(Z )-6-Azidohex-2-enyl]-6,6,9-trimethyl-6a,7,10,10a-tetrahydrobenzo[c ]chromen-1-ol
PubChem
CID
Formula C 22 H 29 N 3 O 2
Molar mass 367.493 g·mol−1 3D model (
JSmol )
CC3=CCC2C(C)(C)Oc(c1C2C3)cc(cc1O)CC=CCCCN=N=N
(verify)
O-1238 is a drug which is a
cannabinoid derivative that is used in scientific research. It is a partial
agonist at the cannabinoid
receptor
CB1 ,
[1] producing a maximal stimulation of 58.3%
[2] with a
Ki of 8.45 nM.
[3]
References
^ Griffin G, Wray EJ, Martin BR, Abood ME (October 1999).
"Cannabinoid agonists and antagonists discriminated by receptor binding in rat cerebellum" . British Journal of Pharmacology . 128 (3): 684–8.
doi :
10.1038/sj.bjp.0702806 .
PMC
1571656 .
PMID
10516649 .
^ Griffin G, Wray EJ, Rorrer WK, Crocker PJ, Ryan WJ, Saha B, et al. (April 1999).
"An investigation into the structural determinants of cannabinoid receptor ligand efficacy" . British Journal of Pharmacology . 126 (7): 1575–84.
doi :
10.1038/sj.bjp.0702469 .
PMC
1565939 .
PMID
10323589 .
^ Ross RA, Gibson TM, Stevenson LA, Saha B, Crocker P, Razdan RK, Pertwee RG (October 1999).
"Structural determinants of the partial agonist-inverse agonist properties of 6'-azidohex-2'-yne-delta8-tetrahydrocannabinol at cannabinoid receptors" . British Journal of Pharmacology . 128 (3): 735–43.
doi :
10.1038/sj.bjp.0702836 .
PMC
1571677 .
PMID
10516656 .
Phytocannabinoids (
comparison )
Cannabibutols Cannabichromenes Cannabicyclols Cannabidiols Cannabielsoins Cannabigerols Cannabiphorols Cannabinols Cannabitriols Cannabivarins Delta-8-tetrahydrocannabinols Delta-9-tetrahydrocannabinols Delta-10-Tetrahydrocannabinols Miscellaneous cannabinoids Active metabolites
Endocannabinoids
Synthetic cannabinoid receptor agonists / neocannabinoids
Classical cannabinoids (dibenzopyrans) Non-classical cannabinoids Adamantoylindoles Benzimidazoles Benzoylindoles Cyclohexylphenols
Eicosanoids
Hydrocarbons Indazole carboxamides Indazole-3- carboxamides Indole-3-carboxamides Indole-3-carboxylates Naphthoylindazoles
Naphthoylindoles Naphthoylpyrroles Naphthylmethylindenes Naphthylmethylindoles Phenylacetylindoles Pyrazolecarboxamides Pyrrolobenzoxazines Quinolinyl esters Tetramethylcyclo- propanoylindazoles Tetramethylcyclo- propanoylindoles Tetramethylcyclo- propylindoles Others
Allosteric
CBR Tooltip Cannabinoid receptor
ligands
Endocannabinoid enhancers (inactivation inhibitors)
Anticannabinoids (antagonists/inverse agonists/antibodies)