URB602 ([1,1'-biphenyl]-3-yl-carbamic acid, cyclohexyl ester) is a compound that has been found to inhibit
hydrolysis of
monoacyl glycerol compounds, such as
2-arachidonoylglycerol (2-AG) and
2-oleoylglycerol (2-OG). It was first described in 2003.[1] A study performed in 2005 found that the compound had specificity for metabolizing 2-AG over
anandamide (another
cannabinoid ligand) in rat brain presumably by inhibiting the enzyme
monoacylglycerol lipase (MAGL), which is the primary metabolic enzyme of 2-AG.[2] However, subsequent studies have shown that URB602 lacks specificity for MAGL inhibition in vitro.[3]