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Chemical compound
O-2694
(6aR ,10aR )-6,6,9-trimethyl-3-(2-methyl-7-morpholin-4-yl-7-oxoheptan-2-yl)-6a,7,10,10a-tetrahydrobenzo[c ]chromen-1-yl 4-(di(propan-2-yl)amino)butanoate
PubChem
CID
ChemSpider
Formula C 38 H 60 N 2 O 5
Molar mass 624.907 g·mol−1 3D model (
JSmol )
O=C(N1CCOCC1)CCCCC(c3cc2OC([C@@H]4C/C=C(\C[C@H]4c2c(OC(=O)CCCN(C(C)C)C(C)C)c3)C)(C)C)(C)C
InChI=1S/C38H60N2O5/c1-26(2)40(27(3)4)18-12-14-35(42)44-32-24-29(37(6,7)17-11-10-13-34(41)39-19-21-43-22-20-39)25-33-36(32)30-23-28(5)15-16-31(30)38(8,9)45-33/h15,24-27,30-31H,10-14,16-23H2,1-9H3/t30-,31-/m1/s1
N Key:OAFUHIZKKMQSAB-FIRIVFDPSA-N
N
N Y
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O-2694 is a drug that is a
cannabinoid derivative. It has
analgesic effects and is used in scientific research. Unlike most cannabinoids discovered to date, it is highly water-soluble, which gives it considerable advantages over many related drugs. It has high affinity for both
CB1 and
CB2
receptors , with
K i values of 3.7 nM at CB1 and 2.8 nM at CB2 . However, it has complex pharmacokinetics as most of the administered dose is metabolised by hydrolysis of the
ester link to the water-insoluble compound
O-2372 , thus producing a biphasic effects profile that is less suitable for research purposes than the related compound
O-2545 .
[1]
See also
References
^ Martin BR, Wiley JL, Beletskaya I, Sim-Selley LJ, Smith FL, Dewey WL, et al. (September 2006). "Pharmacological characterization of novel water-soluble cannabinoids". The Journal of Pharmacology and Experimental Therapeutics . 318 (3): 1230–9.
doi :
10.1124/jpet.106.104109 .
PMID
16757541 .
S2CID
14864925 .
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comparison )
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