From Wikipedia, the free encyclopedia
O-1918
Identifiers
  • 1,3-dimethoxy-5-methyl-2-[(1R,6R)-3-methyl-6-prop-1-en-2-ylcyclohex-2-en-1-yl]benzene
CAS Number
PubChem CID
UNII
CompTox Dashboard ( EPA)
Chemical and physical data
FormulaC19H26O2
Molar mass286.415 g·mol−1
3D model ( JSmol)
  • CC1=C[C@@H](C2=C(OC)C=C(C)C=C2OC)[C@H](C(C)=C)CC1

O-1918 is a synthetic compound related to cannabidiol, which is an antagonist at two former orphan receptors GPR18 and GPR55, that appear to be related to the cannabinoid receptors. O-1918 is used in the study of these receptors, which have been found to be targets for a number of endogenous and synthetic cannabinoid compounds, and are thought to be responsible for most of the non-CB1, non-CB2 mediated effects that have become evident in the course of cannabinoid research. [1] [2] [3] [4] [5]

Subsequent research by using electrophysiological approach has shown that O-1918 is a potent BKCa channel inhibitor. [6] [7] [8]

See also

References

  1. ^ Offertáler L, Mo FM, Bátkai S, Liu J, Begg M, Razdan RK, et al. (March 2003). "Selective ligands and cellular effectors of a G protein-coupled endothelial cannabinoid receptor". Molecular Pharmacology. 63 (3): 699–705. doi: 10.1124/mol.63.3.699. PMID  12606780.
  2. ^ Zakrzeska A, Schlicker E, Baranowska M, Kozłowska H, Kwolek G, Malinowska B (June 2010). "A cannabinoid receptor, sensitive to O-1918, is involved in the delayed hypotension induced by anandamide in anaesthetized rats". British Journal of Pharmacology. 160 (3): 574–84. doi: 10.1111/j.1476-5381.2009.00579.x. PMC  2931558. PMID  20105178.
  3. ^ Schuelert N, McDougall JJ (August 2011). "The abnormal cannabidiol analogue O-1602 reduces nociception in a rat model of acute arthritis via the putative cannabinoid receptor GPR55". Neuroscience Letters. 500 (1): 72–6. doi: 10.1016/j.neulet.2011.06.004. PMID  21683763. S2CID  3410391.
  4. ^ Szczesniak AM, Maor Y, Robertson H, Hung O, Kelly ME (October 2011). "Nonpsychotropic cannabinoids, abnormal cannabidiol and canabigerol-dimethyl heptyl, act at novel cannabinoid receptors to reduce intraocular pressure". Journal of Ocular Pharmacology and Therapeutics. 27 (5): 427–35. doi: 10.1089/jop.2011.0041. PMID  21770780.
  5. ^ Caldwell MD, Hu SS, Viswanathan S, Bradshaw H, Kelly ME, Straiker A (June 2013). "A GPR18-based signalling system regulates IOP in murine eye". British Journal of Pharmacology. 169 (4): 834–43. doi: 10.1111/bph.12136. PMC  3687663. PMID  23461720.
  6. ^ Godlewski G, Offertáler L, Osei-Hyiaman D, Mo FM, Harvey-White J, Liu J, et al. (January 2009). "The endogenous brain constituent N-arachidonoyl L-serine is an activator of large conductance Ca2+-activated K+ channels". The Journal of Pharmacology and Experimental Therapeutics. 328 (1): 351–361. doi: 10.1124/jpet.108.144717. PMC  2605781. PMID  18923087.
  7. ^ Bondarenko AI, Panasiuk O, Drachuk K, Montecucco F, Brandt KJ, Mach F (March 2018). "The quest for endothelial atypical cannabinoid receptor: BKCa channels act as cellular sensors for cannabinoids in in vitro and in situ endothelial cells". Vascular Pharmacology. 102: 44–55. doi: 10.1016/j.vph.2018.01.004. PMC  6481560. PMID  29355732.
  8. ^ Bondarenko AI, Panasiuk O, Okhai I, Montecucco F, Brandt KJ, Mach F (June 2017). "Direct activation of Ca2+ and voltage-gated potassium channels of large conductance by anandamide in endothelial cells does not support the presence of endothelial atypical cannabinoid receptor". European Journal of Pharmacology. 805: 14–24. doi: 10.1016/j.ejphar.2017.03.038. PMC  6520242. PMID  28327344.
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