L-759,656 is an
analgesic drug that is a
cannabinoidagonist. It is a highly selective agonist for the
CB2receptor, with selectivity of 414x for CB2 over CB1,[1] although it is still not as selective as newer agents such as
HU-308.
It produces some similar effects to other cannabinoid agonists such as
analgesia, but with little or no
sedative or
psychoactive effects due to its weak
CB1 activity, and a relatively strong
antiinflammatory effect due to its strong activity at CB2.[2][3]
^Huffman JW (September 2000). "The search for selective ligands for the CB2 receptor". Current Pharmaceutical Design. 6 (13): 1323–37.
doi:
10.2174/1381612003399347.
PMID10903395.