4-Nonylphenylboronic acid is a potent and selective inhibitor of the enzyme
fatty acid amide hydrolase (FAAH), with an IC50 of 9.1nM, and 870x selectivity for FAAH over the related enzyme
MAGL, which it inhibits with an IC50 of 7900nM.[1] It is also a weaker inhibitor of the enzymes
endothelial lipase and
lipoprotein lipase, with
IC50 values of 100 nM and 1400 nM respectively.[2]
^Minkkilä A, Saario SM, Käsnänen H, Leppänen J, Poso A, Nevalainen T (November 2008). "Discovery of boronic acids as novel and potent inhibitors of fatty acid amide hydrolase". Journal of Medicinal Chemistry. 51 (22): 7057–60.
doi:
10.1021/jm801051t.
PMID18983140.