Nonabine (BRL-4664) is an experimental drug which is a synthetic
THCanalog.[1] It was studied in the 1980s for the prevention of
nausea and
vomiting associated with
cancerchemotherapy but was never marketed.[1] It has strong
antiemetic effects equivalent to those of
chlorpromazine, and also produces some mild
sedative effects, along with
dry mouth and
EEG changes typical of
cannabinoid agonists, but with minimal changes in mood or perception, suggesting the abuse potential is likely to be low.[2][3]
References
^
abStaquet M, Bron D, Rozencweig M, Kenis Y (1981). "Clinical studies with a THC analog (BRL-4664) in the prevention of cisplatin-induced vomiting". Journal of Clinical Pharmacology. 21 (S1): 60S–63S.
doi:
10.1002/j.1552-4604.1981.tb02575.x.
PMID7197692.
S2CID30609591.
^McClelland GR, Sutton JA (1985). "Pilot investigation of the quantitative EEG and clinical effects of ketazolam and the novel antiemetic nonabine in normal subjects". Psychopharmacology. 85 (3): 306–8.
doi:
10.1007/BF00428192.
PMID2860687.
S2CID19560039.