O-1871 is a potent
cannabinoid agonist which was invented by Billy R Martin and Raj K Razdan at
Organix Inc in 2002. It has a
CB1 receptor affinity of 2.0 nM and a
CB2 receptor affinity of 0.3 nM.[1] Structurally, O-1871 is a cyclohexylphenol derivative related to
CP 47,497,[2] and so is illegal in some jurisdictions where CP 47,497 and its derivatives are banned. However the 3,3-dimethylcyclohexyl substituent of O-1871 can be replaced by various other groups, producing other potent compounds such as the cycloheptyl derivative
O-1656 and the 2-adamantyl derivative O-1660, as well as the corresponding 3,5-dichlorophenyl derivative,[3] which are not cyclohexylphenol derivatives.
^US application 2004087590, Lai XZ, Lu D,
Makriyannis A, "Novel biphenyl and biphenyl-like cannabinoids", published 6 May 2004, assigned to University of Connecticut