9-Hydroxyhexahydrocannabinol (9-OH-HHC) is a semi-synthetic derivative of
tetrahydrocannabinol. It is formed as an impurity in the synthesis of
Delta-8-THC,[1] and retains activity in animal studies though with only around 1/10 the potency of Δ9-THC, with the 9α- and 9β- enantiomers having around the same potency.[2]
^Garrett ER, Gouyette AJ, Roseboom H (January 1978). "Stability of tetrahydrocannabinols II". Journal of Pharmaceutical Sciences. 67 (1): 27–32.
doi:
10.1002/jps.2600670108.
PMID22740.
^Reggio PH, McGaughey GB, Odear DF, Seltzman HH, Compton DR, Martin BR (November 1991). "A rational search for the separation of psychoactivity and analgesia in cannabinoids". Pharmacology, Biochemistry, and Behavior. 40 (3): 479–86.
doi:
10.1016/0091-3057(91)90350-b.
PMID1806940.
S2CID23939720.