A-836,339 is a drug developed by
Abbott Laboratories that acts as a potent
cannabinoidreceptorfull agonist. It is selective for
CB2, with
Ki values of 0.64 nM at CB2 vs 270 nM at the psychoactive
CB1 receptor, but while it exhibits selective
analgesic,
anti-inflammatory and
anti-hyperalgesic effects at low doses,[1] its high
efficacy at both targets results in typical cannabis-like effects appearing at higher doses, despite its low binding affinity for CB1.[2] In 2012 A-836,339 was detected via
X-ray crystallography in a "dubious product" sold in Japan, though the product was described as a white powder, not
herbal incense, it was suggested to be for human consumption.[3]
References
^McGaraughty S, Chu KL, Dart MJ, Yao BB, Meyer MD (February 2009). "A CB(2) receptor agonist, A-836339, modulates wide dynamic range neuronal activity in neuropathic rats: contributions of spinal and peripheral CB(2) receptors". Neuroscience. 158 (4): 1652–61.
doi:
10.1016/j.neuroscience.2008.11.015.
PMID19063946.
S2CID207244894.
^Yao BB, Hsieh G, Daza AV, Fan Y, Grayson GK, Garrison TR, et al. (January 2009). "Characterization of a cannabinoid CB2 receptor-selective agonist, A-836339 [2,2,3,3-tetramethyl-cyclopropanecarboxylic acid [3-(2-methoxy-ethyl)-4,5-dimethyl-3H-thiazol-(2Z)-ylidene]-amide], using in vitro pharmacological assays, in vivo pain models, and pharmacological magnetic resonance imaging". The Journal of Pharmacology and Experimental Therapeutics. 328 (1): 141–51.
doi:
10.1124/jpet.108.145011.
PMID18931146.
S2CID46602629.
^Uemura N, Fukaya H, Kanai C, Yoshida M, Nakajima JI, Takahashi M, et al. (2013). "Identification of a synthetic cannabinoid A-836339 as a novel compound found in a product". Forensic Toxicology. 32: 45–50.
doi:
10.1007/s11419-013-0201-x.
S2CID24846364.