Upstate South Carolina
|Greenville–Spartanburg–Anderson, SC Combined Statistical Area|
Location of the Greenville-Spartanburg-Anderson CSA, which coincides with Upstate South Carolina except for Abbeville County, and its components:
Greenville–Anderson Metropolitan Statistical Area
Spartanburg Metropolitan Statistical Area
Seneca Micropolitan Statistical Area
Greenwood Micropolitan Statistical Area
Gaffney Micropolitan Statistical Area
Union Micropolitan Statistical Area
|• Total||6,168 sq mi (15,980 km2)|
|• Land||6,008 sq mi (15,560 km2)|
|• Water||141 sq mi (370 km2) 2.2%|
|• CSA||1,409,582  (40th)|
|Time zone||UTC−5 ( EST)|
|• Summer ( DST)||UTC−4 ( EDT)|
The Upstate is the region in the westernmost part of South Carolina, United States, also known as the Upcountry,  which is the historical term. Although loosely defined among locals, the general definition includes the ten counties of the commerce-rich I-85 corridor in the northwest corner of South Carolina. This definition coincided with the Greenville–Spartanburg–Anderson, SC Combined Statistical Area, as first defined by the Office of Management and Budget in 2015. In 2018, the OMB redefined the CSA such that it no longer included Abbeville County. That definition remains as of 2020.  The region's population was 1,347,112 as of 2016. Situated between Atlanta and Charlotte, the Upstate is[ when?] the geographical center of the Charlanta mega-region. After BMW's initial investment, foreign companies, including others from Germany, have a substantial presence in the Upstate; several large corporations have established regional, national, or continental headquarters in the area. Greenville is the largest city in the region with a population of 67,453 and an urban-area population of 400,492, and it is the base of most commercial activity. Spartanburg and Anderson are next in population.
|County||2019 Estimate||2010 Census||Change|
As of 2018, the Greenville–Spartanburg–Anderson CSA includes all counties in the Upstate except for Abbeville County. Within the CSA are a total of two Metropolitan Statistical Areas and four Micropolitan Statistical Areas. 
As of the 2010 Census, the Greenville–Spartanburg–Anderson CSA had a population of 1,362,073.
|Greenville–Anderson–Mauldin||Greenville, Anderson, Pickens, Laurens||824,112|
The following population rankings are based on the 2010 Census 
The OMB labelled Mauldin and Easley as principal cities from 2015 to 2018.
If students from Clemson University are included, Clemson has close to 30,000 residents.
Communities in the Upstate with under 10,000 residents include:
According to the 2010 Census, no town in the Upstate has a population greater than 6000.
The following table shows the major institutions of higher education in the Upstate.
In 2008, U.S. News ranked Furman as the 37th best liberal arts college, Wofford College as the 59th best, and Presbyterian College as the 101st best.[ citation needed] Also, they ranked Clemson University as the 67th best national university.[ citation needed] According to the Bob Jones University, its Museum and Gallery constitutes the largest collection of religious art in the Western Hemisphere. 
The majority of business and commerce in the Upstate takes place in Greenville County. Greenville has the largest concentration of businesses and financial institutions in its downtown area. In fact, the Greenville-Spartanburg-Anderson MSA was ranked seventh in the nation by site consultants considering the top markets for economic development. Many financial institutions have regional offices located in downtown Greenville. These include Bank of America and the now-defunct Wachovia. Other major industries of commerce in the Upstate include the auto industry which is concentrated mainly along the corridor between Greenville and Spartanburg around the BMW manufacturing facility in Greer. The other major industry in the Upstate is the healthcare and pharmaceuticals. Greenville Hospital System and Bon Secours St. Francis Health System are the area's largest in the healthcare sector, while the pharmaceutical corporation of Bausch & Lomb have set up regional operations alongside smaller recently developed local companies like IRIX Manufacturing, Incorporated and Pharmaceutical Associates. The Upstate is also home to a large amount of private sector and university-based research including R&D facilities for Michelin, Fuji and General Electric and research centers to support the automotive, life sciences, plastics and photonics industries. Clemson University, BMW, IBM, Microsoft, and Michelin have combined their resources to create International Center for Automotive Research (ICAR), a research park that specializes in the development of automotive technology.
The following corporations have a major presence in the Upstate: Adidas, Advance America, Bank of America, BMW of North America, Bon Secours St. Francis Health System , Bosch North America, Bowater, Denny's Restaurants, Dunlop Slazenger Group, Ernst & Young, Fluor Corporation, Freightliner LLC, GE Power Systems, Greenville Hospital System , IBM, Kemet Corporation, Liberty Corporation, Mary Black Health System, Michelin of North America, Microsoft, Milliken & Co., Spartanburg Regional Health System, Spectrum Communications, SunTrust, Ovation Brands, Perrigo Company of South Carolina, Toronto-Dominion Bank, and Verizon.
• BMW's only North American manufacturing plant is located in Spartanburg County, with an investment of $3.7 billion. 
• Michelin North America's headquarters is located in Greenville, along with seven manufacturing plants, R&D facility and test track located in the Upstate. Michelin employs more than 7,800 in South Carolina. 
• Walgreens has their southeastern distribution center located in Anderson County, which employs mentally handicapped workers as nearly 40% of their workforce. 
The Upstate is served by two major interstate highways, I-85 and I-26. Other major interstate spurs include I-185, I-385, and I-585. The major airport in the region is Greenville-Spartanburg International Airport, located nearly halfway between Greenville and Spartanburg in suburban Greer. Greenville, Spartanburg, Anderson, Clemson, Pickens, Union, and Gaffney each have smaller airfields. AMTRAK service along the Crescent Line stops in Spartanburg, Greenville, and Clemson.
The Upstate region is served by 3 regional newspapers: The Greenville News, the (Spartanburg) Herald-Journal and the Anderson Independent-Mail, each of which serves their individual city and surrounding area respectively.
The Upstate is part of the vastly larger Greenville-Spartanburg-Anderson- Asheville designated market area, which extends into western North Carolina and northeastern Georgia. The following television stations serve the region:
- WYFF Channel 4 – Greenville ( NBC)
- WSPA-TV Channel 7 – Spartanburg ( CBS)
- WLOS-TV Channel 13 – Asheville, North Carolina ( ABC)
- WGGS-TV Channel 16 – Greenville ( TBN)
- WHNS Channel 21 – Greenville ( Fox)
- WNTV Channel 29 – Greenville ( SCETV)
- WUNF-TV Channel 33 – Asheville ( UNC-TV)
- WMYA-TV Channel 40 – Anderson ( MNTV)
- WYCW Channel 62 – Asheville ( CW)
- Piedmont Atlantic
- SC-NC-VA Tornado Outbreak
- List of Appalachian Regional Commission counties#South Carolina
- South Carolina Lowcountry
- Midlands of South Carolina
- "Annual Estimates of the Resident Population: April 1, 2010 to July 1, 2014 – United States -- Combined Statistical Area; and for Puerto Rico". US Census Bureau. Archived from the original on February 14, 2020. Retrieved January 7, 2016.
- Hollis, Daniel Walker, University of South Carolina, Volume I, South Carolina College, 1951, Columbia: University of South Carolina Press, p 342
- "OMB Bulletin No. 20-01, Revised Delineations of Metropolitan Statistical Areas, Micropolitan Statistical Areas, and Combined Statistical Areas, and Guidance on Uses of Delineations of These Areas" (PDF). United States Office of Management and Budget. March 6, 2020. Retrieved April 25, 2020.
- See http://factfinder.census.gov for population numbers and for municipality and CDP lists.
- M & G at Bob Jones University
|Wikivoyage has a travel guide for Upstate South Carolina.|
- The Upcountry website – Six Upstate counties form the "Upcountry" tourism region
- South Carolina Appalachian Council of Governments – This council of governments covers the "Upcountry" counties.
- Old 96 Distrist – Three Upstate counties form a part of the Old 96 District tourism region.
- Union County is one of the seven counties in the Olde English District.
- Ten at the Top – A nonprofit organization promoting a shared vision between the political, business and community leaders of the Upstate
- The Greenville News – local newspaper of Greenville
- (Spartanburg) Herald Journal – local newspaper of Spartanburg
- Anderson Independent-Mail – local newspaper of Anderson
- Greenville Journal – a weekly newspaper
- Upstate International - Global Community of the Upstate