From Wikipedia, the free encyclopedia
Protein family
CD120 (C luster of D ifferentiation 120) can refer to two members of the
tumor necrosis factor receptor superfamily:
tumor necrosis factor receptor 1 (TNFR1) and
tumor necrosis factor receptor 2 (TNFR2).
[1]
[2]
Receptor subtypes
There are two variants of the receptor, each encoded by a separate gene:
CD120a - TNFR1 - TNFR superfamily member 1A
CD120b - TNFR2 - TNFR superfamily member 1B
TNFR1 is the receptor type responsible for mediation of TNF-alpha induced sickness behavior,
[3] and is involved in neurotoxic processes.
[4] Elevated levels of TNFR1 has been found in severe mental disorders.
[5]
Signaling pathway
Signaling pathway of
TNF -R1. Dashed grey lines represent multiple steps
See also
References
^ Locksley RM, Killeen N, Lenardo MJ (2001).
"The TNF and TNF receptor superfamilies: integrating mammalian biology" . Cell . 104 (4): 487–501.
doi :
10.1016/S0092-8674(01)00237-9 .
PMID
11239407 .
S2CID
7657797 .
^ Hehlgans T, Pfeffer K (2005).
"The intriguing biology of the tumour necrosis factor/tumour necrosis factor receptor superfamily: players, rules and the games" . Immunology . 115 (1): 1–20.
doi :
10.1111/j.1365-2567.2005.02143.x .
PMC
1782125 .
PMID
15819693 .
^ Palin K, Bluthé RM, McCusker RH, Levade T, Moos F, Dantzer R, Kelley KW (January 2009).
"The type 1 TNF receptor and its associated adapter protein, FAN, are required for TNFalpha-induced sickness behavior" . Psychopharmacology . 201 (4): 549–56.
doi :
10.1007/s00213-008-1331-4 .
PMC
2711641 .
PMID
18825372 .
^ McCoy MK, Tansey MG (2008).
"TNF signaling inhibition in the CNS: implications for normal brain function and neurodegenerative disease" . J Neuroinflammation . 5 (1): 45.
doi :
10.1186/1742-2094-5-45 .
PMC
2577641 .
PMID
18925972 .
^ Hope S, Melle I, Aukrust P, Steen NE, Birkenaes AB, Lorentzen S, Agartz I, Ueland T, Andreassen OA (November 2009). "Similar immune profile in bipolar disorder and schizophrenia: selective increase in soluble tumor necrosis factor receptor I and von Willebrand factor". Bipolar Disord . 11 (7): 726–34.
doi :
10.1111/j.1399-5618.2009.00757.x .
hdl :
10852/34620 .
PMID
19839997 .
External links
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Chemokine
CSF
Interferon
IFNAR (α/β, I)
Agonists:
Albinterferon
Interferon alpha (interferon alfa, IFN-α)
Interferon alfa (
IFNA1 ,
IFNA2 ,
IFNA4 ,
IFNA5 ,
IFNA6 ,
IFNA7 ,
IFNA8 ,
IFNA10 ,
IFNA13 ,
IFNA14 ,
IFNA16 ,
IFNA17 ,
IFNA21 )
Interferon alfa 2a
Interferon alfa 2b
Interferon alfa n1
Interferon alfacon-1
Interferon alpha-n3
Interferon beta (IFN-β) (
IFNB1 ,
IFNB3 )
Interferon beta 1a
Interferon beta 1b
Interferon kappa (IFN-ε/κ/τ/ζ, IFNK)
Interferon omega (IFN-ω, IFNW1)
Peginterferon alfa-2a
Peginterferon alfa-2b
IFNGR (γ, II)
IFNLR (λ, III)
See IL-28R (IFNLR)
here instead.
Interleukin
TGFβ
TNF Others