Integrin alpha-V is a
protein that in humans is encoded by the ITGAVgene.[5]
Function
ITGAV encodes
integrin alpha chain V. Integrins are
heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. Alpha V undergoes post-translational cleavage to yield
disulfide-linked heavy and light chains, that combine with multiple integrin beta chains to form different integrins. Among the known associating beta chains (beta chains 1,3,5,6, and 8;
ITGB1,
ITGB3,
ITGB5,
ITGB6, and
ITGB8), each can interact with
extracellular matrix ligands; the alpha V beta 3 integrin, perhaps the most studied of these, is referred to as the Vitronectin receptor (VNR). In addition to adhesion, many integrins are known to facilitate signal transduction.[6]
Alpha V class integrins
In mammals the
integrins that include alpha-V are :
^Waisberg J, De Souza VL, Affonso Junior RJ, Silva SR, Denadai MV, Margeotto FB, De Souza CS, Matos D (2014). "Overexpression of the ITGAV gene is associated with progression and spread of colorectal cancer". Anticancer Res. 34 (10): 5599–607.
PMID25275062.
Horton MA (May 1997). "The alpha v beta 3 integrin "vitronectin receptor"". The International Journal of Biochemistry & Cell Biology. 29 (5): 721–5.
doi:
10.1016/S1357-2725(96)00155-0.
PMID9251239.
Porter JC, Hogg N (October 1998). "Integrins take partners: cross-talk between integrins and other membrane receptors". Trends in Cell Biology. 8 (10): 390–6.
doi:
10.1016/S0962-8924(98)01344-0.
PMID9789327.