From Wikipedia, the free encyclopedia
Protein-coding gene in the species Homo sapiens
SIGLEC7
Available structures
PDB Human UniProt search:
PDBe
RCSB
Identifiers
Aliases
SIGLEC7 , AIRM1, CD328, CDw328, D-siglec, QA79, SIGLEC-7, SIGLEC19P, SIGLECP2, p75, p75/AIRM1, sialic acid binding Ig like lectin 7, AIRM-1External IDs
OMIM :
604410
HomoloGene :
130668
GeneCards :
SIGLEC7
Wikidata
Sialic acid-binding Ig-like lectin 7 is a
protein that in humans is encoded by the SIGLEC7
gene .
[3]
[4] SIGLEC7 has also been designated as CD328 (
cluster of differentiation 328).
References
^
a
b
c
GRCh38: Ensembl release 89: ENSG00000168995 –
Ensembl , May 2017
^
"Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^ Nicoll G, Ni J, Liu D, Klenerman P, Munday J, Dubock S, Mattei MG, Crocker PR (Dec 1999).
"Identification and characterization of a novel siglec, siglec-7, expressed by human natural killer cells and monocytes" . J Biol Chem . 274 (48): 34089–95.
doi :
10.1074/jbc.274.48.34089 .
PMID
10567377 .
^
"Entrez Gene: SIGLEC7 sialic acid binding Ig-like lectin 7" .
Further reading
Reif K, Buday L, Downward J, Cantrell DA (1994).
"SH3 domains of the adapter molecule Grb2 complex with two proteins in T cells: the guanine nucleotide exchange protein Sos and a 75-kDa protein that is a substrate for T cell antigen receptor-activated tyrosine kinases" . J. Biol. Chem . 269 (19): 14081–7.
doi :
10.1016/S0021-9258(17)36757-1 .
PMID
8188688 .
Falco M, Biassoni R, Bottino C, et al. (1999).
"Identification and molecular cloning of p75/AIRM1, a novel member of the sialoadhesin family that functions as an inhibitory receptor in human natural killer cells" . J. Exp. Med . 190 (6): 793–802.
doi :
10.1084/jem.190.6.793 .
PMC
2195632 .
PMID
10499918 .
Ye X, Mehlen P, Rabizadeh S, et al. (1999).
"TRAF family proteins interact with the common neurotrophin receptor and modulate apoptosis induction" . J. Biol. Chem . 274 (42): 30202–8.
doi :
10.1074/jbc.274.42.30202 .
PMID
10514511 .
Vitale C, Romagnani C, Falco M, et al. (2000).
"Engagement of p75/AIRM1 or CD33 inhibits the proliferation of normal or leukemic myeloid cells" . Proc. Natl. Acad. Sci. U.S.A . 96 (26): 15091–6.
doi :
10.1073/pnas.96.26.15091 .
PMC
24778 .
PMID
10611343 .
Angata T, Varki A (2000).
"Siglec-7: a sialic acid-binding lectin of the immunoglobulin superfamily" . Glycobiology . 10 (4): 431–8.
doi :
10.1093/glycob/10.4.431 .
PMID
10764831 .
Ito A, Handa K, Withers DA, et al. (2001).
"Binding specificity of siglec7 to disialogangliosides of renal cell carcinoma: possible role of disialogangliosides in tumor progression" . FEBS Lett . 498 (1): 116–20.
doi :
10.1016/S0014-5793(01)02476-0 .
PMID
11389909 .
S2CID
6755832 .
Mingari MC, Vitale C, Romagnani C, et al. (2001). "Regulation of myeloid cell proliferation and survival by p75/AIRM1 and CD33 surface receptors". Progress in Basic and Clinical Immunology . Advances in Experimental Medicine and Biology. Vol. 495. pp. 55–61.
doi :
10.1007/978-1-4615-0685-0_8 .
ISBN
978-1-4613-5194-8 .
PMID
11774609 .
Yousef GM, Ordon MH, Foussias G, Diamandis EP (2002). "Genomic organization of the siglec gene locus on chromosome 19q13.4 and cloning of two new siglec pseudogenes". Gene . 286 (2): 259–70.
doi :
10.1016/S0378-1119(02)00432-8 .
PMID
11943481 .
Alphey MS, Attrill H, Crocker PR, van Aalten DM (2003).
"High resolution crystal structures of Siglec-7. Insights into ligand specificity in the Siglec family" . J. Biol. Chem . 278 (5): 3372–7.
doi :
10.1074/jbc.M210602200 .
PMID
12438315 .
Strausberg RL, Feingold EA, Grouse LH, et al. (2003).
"Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899–903.
Bibcode :
2002PNAS...9916899M .
doi :
10.1073/pnas.242603899 .
PMC
139241 .
PMID
12477932 .
Nicoll G, Avril T, Lock K, et al. (2003).
"Ganglioside GD3 expression on target cells can modulate NK cell cytotoxicity via siglec-7-dependent and -independent mechanisms" . Eur. J. Immunol . 33 (6): 1642–8.
doi :
10.1002/eji.200323693 .
PMID
12778482 .
S2CID
7541832 .
Dimasi N, Moretta A, Moretta L, et al. (2004). "Structure of the saccharide-binding domain of the human natural killer cell inhibitory receptor p75/AIRM1". Acta Crystallogr. D . 60 (Pt 2): 401–3.
doi :
10.1107/S0907444903028439 .
PMID
14747738 .
Ikehara Y, Ikehara SK, Paulson JC (2004).
"Negative regulation of T cell receptor signaling by Siglec-7 (p70/AIRM) and Siglec-9" . J. Biol. Chem . 279 (41): 43117–25.
doi :
10.1074/jbc.M403538200 .
PMID
15292262 .
Avril T, Floyd H, Lopez F, et al. (2005).
"The membrane-proximal immunoreceptor tyrosine-based inhibitory motif is critical for the inhibitory signaling mediated by Siglecs-7 and -9, CD33-related Siglecs expressed on human monocytes and NK cells" . J. Immunol . 173 (11): 6841–9.
doi :
10.4049/jimmunol.173.11.6841 .
PMID
15557178 .
Yamaji T, Mitsuki M, Teranishi T, Hashimoto Y (2005).
"Characterization of inhibitory signaling motifs of the natural killer cell receptor Siglec-7: attenuated recruitment of phosphatases by the receptor is attributed to two amino acids in the motifs" . Glycobiology . 15 (7): 667–76.
doi :
10.1093/glycob/cwi048 .
PMID
15703304 .
Attrill H, Takazawa H, Witt S, et al. (2006).
"The structure of siglec-7 in complex with sialosides: leads for rational structure-based inhibitor design" . Biochem. J . 397 (2): 271–8.
doi :
10.1042/BJ20060103 .
PMC
1513286 .
PMID
16623661 .
Rapoport EM, Pazynina GV, Sablina MA, et al. (2006). "Probing sialic acid binding Ig-like lectins (siglecs) with sulfated oligosaccharides". Biochemistry Mosc . 71 (5): 496–504.
doi :
10.1134/S0006297906050051 .
PMID
16732727 .
S2CID
11537303 .
Biedermann B, Gil D, Bowen DT, Crocker PR (2007). "Analysis of the CD33-related siglec family reveals that Siglec-9 is an endocytic receptor expressed on subsets of acute myeloid leukemia cells and absent from normal hematopoietic progenitors". Leuk. Res . 31 (2): 211–20.
doi :
10.1016/j.leukres.2006.05.026 .
PMID
16828866 .
PDB gallery
1nko : Energetic and structural basis of sialylated oligosaccharide recognition by the natural killer cell inhibitory receptor p75/AIRM1 or Siglec-7
1o7s : HIGH RESOLUTION STRUCTURE OF SIGLEC-7
1o7v : HIGH RESOLUTION STRUCTURE OF SIGLEC-7
2df3 : The structure of Siglec-7 in complex with alpha(2,3)/alpha(2,6) disialyl lactotetraosyl 2-(trimethylsilyl)ethyl
2g5r : Crystal structure of Siglec-7 in complex with methyl-9-(aminooxalyl-amino)-9-deoxyNeu5Ac (oxamido-Neu5Ac)
2hrl : Siglec-7 in complex with GT1b
External links
This article incorporates text from the
United States National Library of Medicine , which is in the
public domain .
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