From Wikipedia, the free encyclopedia
JAK1
Available structures
PDB Ortholog search:
PDBe
RCSB List of PDB id codes
3EYG ,
3EYH ,
4E4L ,
4E4N ,
4E5W ,
4EHZ ,
4EI4 ,
4FK6 ,
4I5C ,
4IVB ,
4IVC ,
4IVD ,
4K6Z ,
4K77 ,
4L00 ,
4L01 ,
5E1E ,
5HX8 ,
5IXD ,
5IXI
Identifiers
Aliases
JAK1 , JAK1A, JAK1B, JTK3, Janus kinase 1, AIIDEExternal IDs
OMIM :
147795
MGI :
96628
HomoloGene :
1678
GeneCards :
JAK1
Wikidata
JAK1 is a human
tyrosine kinase protein essential for signaling for certain type I and type II
cytokines . It interacts with the
common gamma chain (γc) of
type I cytokine receptors , to elicit signals from the
IL-2 receptor family (e.g.
IL-2R ,
IL-7R ,
IL-9R and
IL-15R ), the
IL-4 receptor family (e.g.
IL-4R and
IL-13R ), the
gp130 receptor family (e.g.
IL-6R ,
IL-11R ,
LIF-R ,
OSM-R ,
cardiotrophin-1 receptor (CT-1R),
ciliary neurotrophic factor receptor (CNTF-R),
neurotrophin-1 receptor (NNT-1R) and
Leptin-R ). It is also important for transducing a signal by type I (
IFN-α /
β ) and type II (
IFN-γ )
interferons , and members of the
IL-10 family via
type II cytokine receptors .
[5] Jak1 plays a critical role in initiating responses to multiple major cytokine receptor families. Loss of Jak1 is lethal in neonatal mice, possibly due to difficulties suckling.
[6] Expression of JAK1 in cancer cells enables individual cells to contract, potentially allowing them to escape their tumor and
metastasize to other parts of the body.
[7]
Interactions
Janus kinase 1 has been shown to
interact with:
ELP2 ,
[8]
GNB2L1
[9]
IL6ST ,
[10]
[11]
[12]
Grb2 ,
[13]
[14]
IL2RB ,
[15]
[16]
[17]
[18]
[19]
IRS1 ,
[20]
[21]
IL10RA ,
[15]
[22]
PTPN11 ,
[23]
[24]
STAM2 ,
[25]
[26]
STAT3 ,
[27]
[28]
STAT5A ,
[29]
STAT5B ,
[29] and
TNFRSF1A .
[30]
[31]
See also
References
^
a
b
c
GRCh38: Ensembl release 89: ENSG00000162434 –
Ensembl , May 2017
^
a
b
c
GRCm38: Ensembl release 89: ENSMUSG00000028530 –
Ensembl , May 2017
^
"Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^
"Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^ Gadina M, Hilton D, Johnston JA, Morinobu A, Lighvani A, Zhou YJ, Visconti R, O'Shea JJ (2001).
"Signaling by type I and II cytokine receptors: ten years after" . Curr. Opin. Immunol . 13 (3): 363–73.
doi :
10.1016/S0952-7915(00)00228-4 .
PMID
11406370 .
^ Rodig SJ, Meraz MA, White JM, Lampe PA, Riley JK, Arthur CD, King KL, Sheehan KC, Yin L, Pennica D, Johnson EM, Schreiber RD (1998).
"Disruption of the Jak1 gene demonstrates obligatory and nonredundant roles of the Jaks in cytokine-induced biologic responses" . Cell . 93 (3): 373–83.
doi :
10.1016/S0092-8674(00)81166-6 .
PMID
9590172 .
S2CID
18684846 .
^ Christian Nordqvist.
"Protein JAK Makes Cancer Cells Contract, So They Can Squeeze Out Of A Tumor" . Medical News Today .
^ Collum RG, Brutsaert S, Lee G, Schindler C (August 2000).
"A Stat3-interacting protein (StIP1) regulates cytokine signal transduction" . Proc. Natl. Acad. Sci. U.S.A . 97 (18): 10120–5.
Bibcode :
2000PNAS...9710120C .
doi :
10.1073/pnas.170192197 .
PMC
27739 .
PMID
10954736 .
^ Usacheva A, Tian X, Sandoval R, Salvi D, Levy D, Colamonici OR (September 2003).
"The WD motif-containing protein RACK-1 functions as a scaffold protein within the type I IFN receptor-signaling complex" . J. Immunol . 171 (6): 2989–94.
doi :
10.4049/jimmunol.171.6.2989 .
PMID
12960323 .
^ Haan C, Is'harc H, Hermanns HM, Schmitz-Van De Leur H, Kerr IM, Heinrich PC, Grötzinger J, Behrmann I (October 2001).
"Mapping of a region within the N terminus of Jak1 involved in cytokine receptor interaction" . J. Biol. Chem . 276 (40): 37451–8.
doi :
10.1074/jbc.M106135200 .
PMID
11468294 .
^ Kim H, Baumann H (December 1997).
"Transmembrane domain of gp130 contributes to intracellular signal transduction in hepatic cells" . J. Biol. Chem . 272 (49): 30741–7.
doi :
10.1074/jbc.272.49.30741 .
PMID
9388212 .
^ Haan C, Heinrich PC, Behrmann I (January 2002).
"Structural requirements of the interleukin-6 signal transducer gp130 for its interaction with Janus kinase 1: the receptor is crucial for kinase activation" . Biochem. J . 361 (Pt 1): 105–11.
doi :
10.1042/0264-6021:3610105 .
PMC
1222284 .
PMID
11742534 .
^ Kim H, Lee YH, Won J, Yun Y (September 2001). "Through induction of juxtaposition and tyrosine kinase activity of Jak1, X-gene product of hepatitis B virus stimulates Ras and the transcriptional activation through AP-1, NF-kappaB, and SRE enhancers". Biochem. Biophys. Res. Commun . 286 (5): 886–94.
doi :
10.1006/bbrc.2001.5496 .
PMID
11527382 .
^ Giorgetti-Peraldi S, Peyrade F, Baron V, Van Obberghen E (December 1995).
"Involvement of Janus kinases in the insulin signaling pathway" . Eur. J. Biochem . 234 (2): 656–60.
doi :
10.1111/j.1432-1033.1995.656_b.x .
PMID
8536716 .
^
a
b Usacheva A, Kotenko S, Witte MM, Colamonici OR (August 2002).
"Two distinct domains within the N-terminal region of Janus kinase 1 interact with cytokine receptors" . J. Immunol . 169 (3): 1302–8.
doi :
10.4049/jimmunol.169.3.1302 .
PMID
12133952 .
^ Miyazaki T, Kawahara A, Fujii H, Nakagawa Y, Minami Y, Liu ZJ, Oishi I, Silvennoinen O, Witthuhn BA, Ihle JN (November 1994). "Functional activation of Jak1 and Jak3 by selective association with IL-2 receptor subunits". Science . 266 (5187): 1045–7.
Bibcode :
1994Sci...266.1045M .
doi :
10.1126/science.7973659 .
PMID
7973659 .
^ Russell SM, Johnston JA, Noguchi M, Kawamura M, Bacon CM, Friedmann M, Berg M, McVicar DW, Witthuhn BA, Silvennoinen O (November 1994).
"Interaction of IL-2R beta and gamma c chains with Jak1 and Jak3: implications for XSCID and XCID" . Science . 266 (5187): 1042–5.
Bibcode :
1994Sci...266.1042R .
doi :
10.1126/science.7973658 .
PMID
7973658 .
^ Zhu MH, Berry JA, Russell SM, Leonard WJ (April 1998).
"Delineation of the regions of interleukin-2 (IL-2) receptor beta chain important for association of Jak1 and Jak3. Jak1-independent functional recruitment of Jak3 to Il-2Rbeta" . J. Biol. Chem . 273 (17): 10719–25.
doi :
10.1074/jbc.273.17.10719 .
PMID
9553136 .
^ Migone TS, Rodig S, Cacalano NA, Berg M, Schreiber RD, Leonard WJ (November 1998).
"Functional cooperation of the interleukin-2 receptor beta chain and Jak1 in phosphatidylinositol 3-kinase recruitment and phosphorylation" . Mol. Cell. Biol . 18 (11): 6416–22.
doi :
10.1128/mcb.18.11.6416 .
PMC
109227 .
PMID
9774657 .
^ Gual P, Baron V, Lequoy V, Van Obberghen E (March 1998).
"Interaction of Janus kinases JAK-1 and JAK-2 with the insulin receptor and the insulin-like growth factor-1 receptor" . Endocrinology . 139 (3): 884–93.
doi :
10.1210/endo.139.3.5829 .
PMID
9492017 .
^ Johnston JA, Wang LM, Hanson EP, Sun XJ, White MF, Oakes SA, Pierce JH, O'Shea JJ (December 1995).
"Interleukins 2, 4, 7, and 15 stimulate tyrosine phosphorylation of insulin receptor substrates 1 and 2 in T cells. Potential role of JAK kinases" . J. Biol. Chem . 270 (48): 28527–30.
doi :
10.1074/jbc.270.48.28527 .
PMID
7499365 .
^ Usacheva A, Sandoval R, Domanski P, Kotenko SV, Nelms K, Goldsmith MA, Colamonici OR (December 2002).
"Contribution of the Box 1 and Box 2 motifs of cytokine receptors to Jak1 association and activation" . J. Biol. Chem . 277 (50): 48220–6.
doi :
10.1074/jbc.M205757200 .
PMID
12374810 .
^ Yin T, Shen R, Feng GS, Yang YC (January 1997).
"Molecular characterization of specific interactions between SHP-2 phosphatase and JAK tyrosine kinases" . J. Biol. Chem . 272 (2): 1032–7.
doi :
10.1074/jbc.272.2.1032 .
PMID
8995399 .
^ Lehmann U, Schmitz J, Weissenbach M, Sobota RM, Hortner M, Friederichs K, Behrmann I, Tsiaris W, Sasaki A, Schneider-Mergener J, Yoshimura A, Neel BG, Heinrich PC, Schaper F (January 2003).
"SHP2 and SOCS3 contribute to Tyr-759-dependent attenuation of interleukin-6 signaling through gp130" . J. Biol. Chem . 278 (1): 661–71.
doi :
10.1074/jbc.M210552200 .
PMID
12403768 .
^ Pandey A, Fernandez MM, Steen H, Blagoev B, Nielsen MM, Roche S, Mann M, Lodish HF (December 2000).
"Identification of a novel immunoreceptor tyrosine-based activation motif-containing molecule, STAM2, by mass spectrometry and its involvement in growth factor and cytokine receptor signaling pathways" . J. Biol. Chem . 275 (49): 38633–9.
doi :
10.1074/jbc.M007849200 .
PMID
10993906 .
^ Endo K, Takeshita T, Kasai H, Sasaki Y, Tanaka N, Asao H, Kikuchi K, Yamada M, Chenb M, O'Shea JJ, Sugamura K (July 2000).
"STAM2, a new member of the STAM family, binding to the Janus kinases" . FEBS Lett . 477 (1–2): 55–61.
doi :
10.1016/s0014-5793(00)01760-9 .
PMID
10899310 .
^ Ueda T, Bruchovsky N, Sadar MD (March 2002).
"Activation of the androgen receptor N-terminal domain by interleukin-6 via MAPK and STAT3 signal transduction pathways" . J. Biol. Chem . 277 (9): 7076–85.
doi :
10.1074/jbc.M108255200 .
PMID
11751884 .
^ Spiekermann K, Biethahn S, Wilde S, Hiddemann W, Alves F (August 2001). "Constitutive activation of STAT transcription factors in acute myelogenous leukemia". Eur. J. Haematol . 67 (2): 63–71.
doi :
10.1034/j.1600-0609.2001.t01-1-00385.x .
PMID
11722592 .
S2CID
38074766 .
^
a
b Fujitani Y, Hibi M, Fukada T, Takahashi-Tezuka M, Yoshida H, Yamaguchi T, Sugiyama K, Yamanaka Y, Nakajima K, Hirano T (February 1997).
"An alternative pathway for STAT activation that is mediated by the direct interaction between JAK and STAT" . Oncogene . 14 (7): 751–61.
doi :
10.1038/sj.onc.1200907 .
PMID
9047382 .
^ Guo D, Dunbar JD, Yang CH, Pfeffer LM, Donner DB (March 1998).
"Induction of Jak/STAT signaling by activation of the type 1 TNF receptor" . J. Immunol . 160 (6): 2742–50.
doi :
10.4049/jimmunol.160.6.2742 .
PMID
9510175 .
^ Miscia S, Marchisio M, Grilli A, Di Valerio V, Centurione L, Sabatino G, Garaci F, Zauli G, Bonvini E, Di Baldassarre A (January 2002). "Tumor necrosis factor alpha (TNF-alpha) activates Jak1/Stat3-Stat5B signaling through TNFR-1 in human B cells". Cell Growth Differ . 13 (1): 13–8.
PMID
11801527 .
Further reading
Donnelly RP, Dickensheets H, Finbloom DS (1999).
"The interleukin-10 signal transduction pathway and regulation of gene expression in mononuclear phagocytes" . J. Interferon Cytokine Res . 19 (6): 563–73.
doi :
10.1089/107999099313695 .
PMID
10433356 .
Carter-Su C, Rui L, Stofega MR (2000). "SH2-B and SIRP: JAK2 binding proteins that modulate the actions of growth hormone". Recent Prog. Horm. Res . 55 : 293–311.
PMID
11036942 .
Kostrodymova GM (1976). "[An experimental study of the possible sensitizing properties of triethanolamine contained in chemical compounds used at home]". Gigiena i Sanitariia (6): 10–2.
PMID
1213395 .
Howard OM, Dean M, Young H, Ramsburg M, Turpin JA, Michiel DF, Kelvin DJ, Lee L, Farrar WL (1992). "Characterization of a class 3 tyrosine kinase". Oncogene . 7 (5): 895–900.
PMID
1373877 .
Pritchard MA, Baker E, Callen DF, Sutherland GR, Wilks AF (1992). "Two members of the JAK family of protein tyrosine kinases map to chromosomes 1p31.3 and 9p24". Mamm. Genome . 3 (1): 36–8.
doi :
10.1007/BF00355839 .
PMID
1581631 .
S2CID
31384629 .
Wilks AF, Harpur AG, Kurban RR, Ralph SJ, Zürcher G, Ziemiecki A (1991).
"Two novel protein-tyrosine kinases, each with a second phosphotransferase-related catalytic domain, define a new class of protein kinase" . Mol. Cell. Biol . 11 (4): 2057–65.
doi :
10.1128/MCB.11.4.2057 .
PMC
359893 .
PMID
1848670 .
Johnston JA, Wang LM, Hanson EP, Sun XJ, White MF, Oakes SA, Pierce JH, O'Shea JJ (1996).
"Interleukins 2, 4, 7, and 15 stimulate tyrosine phosphorylation of insulin receptor substrates 1 and 2 in T cells. Potential role of JAK kinases" . J. Biol. Chem . 270 (48): 28527–30.
doi :
10.1074/jbc.270.48.28527 .
PMID
7499365 .
Nicholson SE, Oates AC, Harpur AG, Ziemiecki A, Wilks AF, Layton JE (1994).
"Tyrosine kinase JAK1 is associated with the granulocyte-colony-stimulating factor receptor and both become tyrosine-phosphorylated after receptor activation" . Proc. Natl. Acad. Sci. U.S.A . 91 (8): 2985–8.
Bibcode :
1994PNAS...91.2985N .
doi :
10.1073/pnas.91.8.2985 .
PMC
43499 .
PMID
7512720 .
Domanski P, Yan H, Witte MM, Krolewski J, Colamonici OR (1995).
"Homodimerization and intermolecular tyrosine phosphorylation of the Tyk-2 tyrosine kinase" . FEBS Lett . 374 (3): 317–22.
doi :
10.1016/0014-5793(95)01094-U .
PMID
7589562 .
Modi WS, Farrar WL, Howard OM (1995).
"Confirmed assignment of a novel human tyrosine kinase gene (JAK1A) to 1p32.3→p31.3 by nonisotopic in situ hybridization" . Cytogenet. Cell Genet . 69 (3–4): 232–4.
doi :
10.1159/000133971 .
PMID
7698020 .
Miyazaki T, Kawahara A, Fujii H, Nakagawa Y, Minami Y, Liu Z, Oishi I, Silvennoinen O, Witthuhn B (1994). "Functional activation of Jak1 and Jak3 by selective association with IL-2 receptor subunits". Science . 266 (5187): 1045–7.
Bibcode :
1994Sci...266.1045M .
doi :
10.1126/science.7973659 .
PMID
7973659 .
Müller M, Briscoe J, Laxton C, Guschin D, Ziemiecki A, Silvennoinen O, Harpur AG, Barbieri G, Witthuhn BA (1993). "The protein tyrosine kinase JAK1 complements defects in interferon-alpha/beta and -gamma signal transduction". Nature . 366 (6451): 129–35.
Bibcode :
1993Natur.366..129M .
doi :
10.1038/366129a0 .
PMID
8232552 .
S2CID
27334189 .
Lee ST, Strunk KM, Spritz RA (1993). "A survey of protein tyrosine kinase mRNAs expressed in normal human melanocytes". Oncogene . 8 (12): 3403–10.
PMID
8247543 .
Lütticken C, Wegenka UM, Yuan J, Buschmann J, Schindler C, Ziemiecki A, Harpur A, Wilks A, Yasukawa K (1994). "Association of transcription factor APRF and protein kinase Jak1 with the interleukin-6 signal transducer gp130". Science . 263 (5143): 89–92.
Bibcode :
1994Sci...263...89L .
doi :
10.1126/science.8272872 .
PMID
8272872 .
Giorgetti-Peraldi S, Peyrade F, Baron V, Van Obberghen E (1996).
"Involvement of Janus kinases in the insulin signaling pathway" . Eur. J. Biochem . 234 (2): 656–60.
doi :
10.1111/j.1432-1033.1995.656_b.x .
PMID
8536716 .
Friedmann MC, Migone TS, Russell SM, Leonard WJ (1996).
"Different interleukin 2 receptor beta-chain tyrosines couple to at least two signaling pathways and synergistically mediate interleukin 2-induced proliferation" . Proc. Natl. Acad. Sci. U.S.A . 93 (5): 2077–82.
Bibcode :
1996PNAS...93.2077F .
doi :
10.1073/pnas.93.5.2077 .
PMC
39912 .
PMID
8700888 .
Gauzzi MC, Velazquez L, McKendry R, Mogensen KE, Fellous M, Pellegrini S (1996).
"Interferon-alpha-dependent activation of Tyk2 requires phosphorylation of positive regulatory tyrosines by another kinase" . J. Biol. Chem . 271 (34): 20494–500.
doi :
10.1074/jbc.271.34.20494 .
PMID
8702790 .
Demoulin JB, Uyttenhove C, Van Roost E, Delestré B, Donckers D, Van Snick J, Renauld JC (1996).
"A single tyrosine of the interleukin-9 (IL-9) receptor is required for STAT activation, antiapoptotic activity, and growth regulation by IL-9" . Mol. Cell. Biol . 16 (9): 4710–6.
doi :
10.1128/MCB.16.9.4710 .
PMC
231471 .
PMID
8756628 .
Yin T, Shen R, Feng GS, Yang YC (1997).
"Molecular characterization of specific interactions between SHP-2 phosphatase and JAK tyrosine kinases" . J. Biol. Chem . 272 (2): 1032–7.
doi :
10.1074/jbc.272.2.1032 .
PMID
8995399 .
Bluyssen HA, Levy DE (1997).
"Stat2 is a transcriptional activator that requires sequence-specific contacts provided by stat1 and p48 for stable interaction with DNA" . J. Biol. Chem . 272 (7): 4600–5.
doi :
10.1074/jbc.272.7.4600 .
PMID
9020188 .
External links
Activity Regulation Classification Kinetics Types
Chemokine
CSF
Interferon
IFNAR (α/β, I)
Agonists:
Albinterferon
Interferon alpha (interferon alfa, IFN-α)
Interferon alfa (
IFNA1 ,
IFNA2 ,
IFNA4 ,
IFNA5 ,
IFNA6 ,
IFNA7 ,
IFNA8 ,
IFNA10 ,
IFNA13 ,
IFNA14 ,
IFNA16 ,
IFNA17 ,
IFNA21 )
Interferon alfa 2a
Interferon alfa 2b
Interferon alfa n1
Interferon alfacon-1
Interferon alpha-n3
Interferon beta (IFN-β) (
IFNB1 ,
IFNB3 )
Interferon beta 1a
Interferon beta 1b
Interferon kappa (IFN-ε/κ/τ/ζ, IFNK)
Interferon omega (IFN-ω, IFNW1)
Peginterferon alfa-2a
Peginterferon alfa-2b
IFNGR (γ, II)
IFNLR (λ, III)
See IL-28R (IFNLR)
here instead.
Interleukin
TGFβ
TNF Others