Interleukin 1 receptor, type I (IL1R1) also known as CD121a (Cluster of Differentiation 121a), is an interleukin receptor. IL1R1 also denotes its human gene. [5]
The protein encoded by this gene is a cytokine receptor that belongs to the interleukin-1 receptor family. This protein is a receptor for interleukin 1 alpha (IL1A), interleukin 1 beta (IL1B), and interleukin 1 receptor antagonist (IL1RA). It is an important mediator involved in many cytokine induced immune and inflammatory responses. This gene along with interleukin 1 receptor, type II (IL1R2), interleukin 1 receptor-like 2 (IL1RL2), and interleukin 1 receptor-like 1 (IL1RL1) form a cytokine receptor gene cluster in a region mapped to chromosome 2q12. [5]
Interactions
Interleukin 1 receptor, type I has been shown to interact with PIK3R1, [6] Myd88 [7] [8] and IL1RAP. [9]
See also
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000115594 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000026072 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ a b "Entrez Gene: IL1R1 interleukin 1 receptor, type I".
- ^ Reddy, S A; Huang J H; Liao W S (November 1997). "Phosphatidylinositol 3-kinase in interleukin 1 signaling. Physical interaction with the interleukin 1 receptor and requirement in NFkappaB and AP-1 activation". J. Biol. Chem. 272 (46). UNITED STATES: 29167–73. doi: 10.1074/jbc.272.46.29167. ISSN 0021-9258. PMID 9360994.
- ^ Burns, K; Clatworthy J; Martin L; Martinon F; Plumpton C; Maschera B; Lewis A; Ray K; Tschopp J; Volpe F (June 2000). "Tollip, a new component of the IL-1RI pathway, links IRAK to the IL-1 receptor". Nat. Cell Biol. 2 (6). ENGLAND: 346–51. doi: 10.1038/35014038. ISSN 1465-7392. PMID 10854325. S2CID 32036101.
- ^ Muzio, M; Ni J; Feng P; Dixit V M (November 1997). "IRAK (Pelle) family member IRAK-2 and MyD88 as proximal mediators of IL-1 signaling". Science. 278 (5343). UNITED STATES: 1612–5. Bibcode: 1997Sci...278.1612M. doi: 10.1126/science.278.5343.1612. ISSN 0036-8075. PMID 9374458.
- ^ Huang, J; Gao X; Li S; Cao Z (November 1997). "Recruitment of IRAK to the interleukin 1 receptor complex requires interleukin 1 receptor accessory protein". Proc. Natl. Acad. Sci. U.S.A. 94 (24). UNITED STATES: 12829–32. Bibcode: 1997PNAS...9412829H. doi: 10.1073/pnas.94.24.12829. ISSN 0027-8424. PMC 24223. PMID 9371760.
Further reading
- Copeland NG, Silan CM, Kingsley DM, et al. (1991). "Chromosomal location of murine and human IL-1 receptor genes". Genomics. 9 (1): 44–50. doi: 10.1016/0888-7543(91)90219-5. PMID 1672292.
- McMahan CJ, Slack JL, Mosley B, et al. (1991). "A novel IL-1 receptor, cloned from B cells by mammalian expression, is expressed in many cell types". EMBO J. 10 (10): 2821–32. doi: 10.1002/j.1460-2075.1991.tb07831.x. PMC 452992. PMID 1833184.
- Uhl J, Newton RC, Giri JG, et al. (1989). "Identification of IL-1 receptors on human monocytes". J. Immunol. 142 (5): 1576–81. doi: 10.4049/jimmunol.142.5.1576. PMID 2521881. S2CID 28462235.
- Sims JE, Acres RB, Grubin CE, et al. (1989). "Cloning the interleukin 1 receptor from human T cells". Proc. Natl. Acad. Sci. U.S.A. 86 (22): 8946–50. Bibcode: 1989PNAS...86.8946S. doi: 10.1073/pnas.86.22.8946. PMC 298407. PMID 2530587.
- Chua AO, Gubler U (1990). "Sequence of the cDNA for the human fibroblast type interleukin-1 receptor". Nucleic Acids Res. 17 (23): 10114. doi: 10.1093/nar/17.23.10114. PMC 335251. PMID 2532321.
- Dower SK, Kronheim SR, Hopp TP, et al. (1987). "The cell surface receptors for interleukin-1 alpha and interleukin-1 beta are identical". Nature. 324 (6094): 266–8. Bibcode: 1986Natur.324..266D. doi: 10.1038/324266a0. PMID 2946959. S2CID 4233242.
- Rautonen N, Rautonen J, Martin NL, Wara DW (1995). "HIV-1 Tat induces cytokine synthesis by uninfected mononuclear cells". AIDS. 8 (10): 1504–6. doi: 10.1097/00002030-199410000-00023. PMID 7818827.
- Vigers GP, Anderson LJ, Caffes P, Brandhuber BJ (1997). "Crystal structure of the type-I interleukin-1 receptor complexed with interleukin-1beta". Nature. 386 (6621): 190–4. Bibcode: 1997Natur.386..190V. doi: 10.1038/386190a0. PMID 9062193. S2CID 4358379.
- Schreuder H, Tardif C, Trump-Kallmeyer S, et al. (1997). "A new cytokine-receptor binding mode revealed by the crystal structure of the IL-1 receptor with an antagonist". Nature. 386 (6621): 194–200. Bibcode: 1997Natur.386..194S. doi: 10.1038/386194a0. PMID 9062194. S2CID 4266953.
- Rameshwar P, Poddar A, Zhu G, Gascón P (1997). "Receptor induction regulates the synergistic effects of substance P with IL-1 and platelet-derived growth factor on the proliferation of bone marrow fibroblasts". J. Immunol. 158 (7): 3417–24. doi: 10.4049/jimmunol.158.7.3417. PMID 9120302. S2CID 24164798.
- Reddy SA, Huang JH, Liao WS (1997). "Phosphatidylinositol 3-kinase in interleukin 1 signaling. Physical interaction with the interleukin 1 receptor and requirement in NFkappaB and AP-1 activation". J. Biol. Chem. 272 (46): 29167–73. doi: 10.1074/jbc.272.46.29167. PMID 9360994.
- Huang J, Gao X, Li S, Cao Z (1998). "Recruitment of IRAK to the interleukin 1 receptor complex requires interleukin 1 receptor accessory protein". Proc. Natl. Acad. Sci. U.S.A. 94 (24): 12829–32. Bibcode: 1997PNAS...9412829H. doi: 10.1073/pnas.94.24.12829. PMC 24223. PMID 9371760.
- Muzio M, Ni J, Feng P, Dixit VM (1997). "IRAK (Pelle) family member IRAK-2 and MyD88 as proximal mediators of IL-1 signaling". Science. 278 (5343): 1612–5. Bibcode: 1997Sci...278.1612M. doi: 10.1126/science.278.5343.1612. PMID 9374458.
- Dale M, Nicklin MJ (1999). "Interleukin-1 receptor cluster: gene organization of IL1R2, IL1R1, IL1RL2 (IL-1Rrp2), IL1RL1 (T1/ST2), and IL18R1 (IL-1Rrp) on human chromosome 2q". Genomics. 57 (1): 177–9. doi: 10.1006/geno.1999.5767. PMID 10191101.
- Sizemore N, Leung S, Stark GR (1999). "Activation of phosphatidylinositol 3-kinase in response to interleukin-1 leads to phosphorylation and activation of the NF-kappaB p65/RelA subunit". Mol. Cell. Biol. 19 (7): 4798–805. doi: 10.1128/mcb.19.7.4798. PMC 84278. PMID 10373529.
- Burns K, Clatworthy J, Martin L, et al. (2000). "Tollip, a new component of the IL-1RI pathway, links IRAK to the IL-1 receptor". Nat. Cell Biol. 2 (6): 346–51. doi: 10.1038/35014038. PMID 10854325. S2CID 32036101.
- Vigers GP, Dripps DJ, Edwards CK, Brandhuber BJ (2001). "X-ray crystal structure of a small antagonist peptide bound to interleukin-1 receptor type 1". J. Biol. Chem. 275 (47): 36927–33. doi: 10.1074/jbc.M006071200. PMID 10903327.
- Lin H, Ho AS, Haley-Vicente D, et al. (2001). "Cloning and characterization of IL-1HY2, a novel interleukin-1 family member". J. Biol. Chem. 276 (23): 20597–602. doi: 10.1074/jbc.M010095200. PMID 11278614.
- Joos L, McIntyre L, Ruan J, et al. (2001). "Association of IL-1beta and IL-1 receptor antagonist haplotypes with rate of decline in lung function in smokers". Thorax. 56 (11): 863–6. doi: 10.1136/thorax.56.11.863. PMC 1745962. PMID 11641511.
- Köller M, Kutscha-Lissberg F, Brom J, et al. (2003). "Influence of low molecular weight heparin (certoparin) and unfractionated heparin on the release of cytokines from human leukocytes". Inflammation. 25 (5): 331–7. doi: 10.1023/A:1012883916991. PMID 11820460. S2CID 21831719.
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External links
- IL1R1+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
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