From Wikipedia, the free encyclopedia
Mammalian protein found in Homo sapiens
ITGA2B
Available structures
PDB Ortholog search:
PDBe
RCSB List of PDB id codes
1DPK ,
1DPQ ,
1KUP ,
1KUZ ,
1M8O ,
1S4W ,
1TYE ,
2K1A ,
2K9J ,
2KNC ,
2MTP ,
2VC2 ,
2VDK ,
2VDL ,
2VDM ,
2VDN ,
2VDO ,
2VDP ,
2VDQ ,
2VDR ,
3FCS ,
3FCU ,
3NID ,
3NIF ,
3NIG ,
3T3M ,
3T3P ,
3ZDX ,
3ZDY ,
3ZDZ ,
3ZE0 ,
3ZE1 ,
3ZE2 ,
4CAK ,
4Z7O ,
4Z7Q ,
5HDB ,
4Z7N
Identifiers
Aliases
ITGA2B , BDPLT16, BDPLT2, CD41, CD41B, GP2B, GPIIb, GT, GTA, HPA3, PPP1R93, integrin subunit alpha 2b, GT1External IDs
OMIM :
607759 ;
MGI :
96601 ;
HomoloGene :
37304 ;
GeneCards :
ITGA2B ;
OMA :
ITGA2B - orthologs
Wikidata
Integrin alpha-IIb is a
protein that in humans is encoded by the ITGA2B
gene . ITGA2B, also known as
CD 41, encodes integrin alpha chain 2b. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. Alpha chain 2b undergoes post-translational cleavage to yield disulfide-linked light and heavy chains that join with beta 3 to form a fibrinogen receptor expressed in platelets that plays a crucial role in coagulation. Mutations that interfere with this role result in thrombasthenia. At least 38 disease-causing mutations in this gene have been discovered.
[5] In addition to adhesion, integrins are known to participate in cell-surface mediated signalling.
[6]
Interactions
ITGA2B has been shown to
interact with
AUP1
[7] and
CLNS1A .
[8]
See also
References
^
a
b
c
GRCh38: Ensembl release 89: ENSG00000005961 –
Ensembl , May 2017
^
a
b
c
GRCm38: Ensembl release 89: ENSMUSG00000034664 –
Ensembl , May 2017
^
"Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^
"Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^ Šimčíková D, Heneberg P (December 2019).
"Refinement of evolutionary medicine predictions based on clinical evidence for the manifestations of Mendelian diseases" . Scientific Reports . 9 (1): 18577.
Bibcode :
2019NatSR...918577S .
doi :
10.1038/s41598-019-54976-4 .
PMC
6901466 .
PMID
31819097 .
^
"Entrez Gene: ITGA2B integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41)" .
^ Kato A, Kawamata Norihiko, Tamayose Kenji, Egashira Motoki, Miura Rika, Fujimura Tsutomu, Murayama Kimie, Oshimi Kazuo (Aug 2002).
"Ancient ubiquitous protein 1 binds to the conserved membrane-proximal sequence of the cytoplasmic tail of the integrin alpha subunits that plays a crucial role in the inside-out signaling of alpha IIbbeta 3" . J. Biol. Chem . 277 (32). United States: 28934–41.
doi :
10.1074/jbc.M204340200 .
ISSN
0021-9258 .
PMID
12042322 .
^ Larkin D, Murphy Derek, Reilly Dermot F, Cahill Martha, Sattler Ellen, Harriott Pat, Cahill Dolores J, Moran Niamh (Jun 2004).
"ICln, a novel integrin alphaIIbbeta3-associated protein, functionally regulates platelet activation" . J. Biol. Chem . 279 (26). United States: 27286–93.
doi :
10.1074/jbc.M402159200 .
ISSN
0021-9258 .
PMID
15075326 .
Further reading
Bray PF (1995). "Inherited diseases of platelet glycoproteins: considerations for rapid molecular characterization". Thromb. Haemost . 72 (4): 492–502.
PMID
7878622 .
Naik UP, Parise LV (1997). "Structure and function of platelet alpha IIb beta 3". Curr. Opin. Hematol . 4 (5): 317–22.
doi :
10.1097/00062752-199704050-00004 .
PMID
9288464 .
Porter JC, Hogg N (1999). "Integrins take partners: cross-talk between integrins and other membrane receptors". Trends Cell Biol . 8 (10): 390–6.
doi :
10.1016/S0962-8924(98)01344-0 .
PMID
9789327 .
Lincoff AM (1998). "Trials of platelet glycoprotein IIb/IIIa receptor antagonists during percutaneous coronary revascularization". Am. J. Cardiol . 82 (8B): 36P–42P.
doi :
10.1016/S0002-9149(98)00662-6 .
PMID
9809890 .
Bennett JS (2001). "Platelet-fibrinogen interactions". Ann. N. Y. Acad. Sci . 936 (1): 340–54.
Bibcode :
2001NYASA.936..340B .
doi :
10.1111/j.1749-6632.2001.tb03521.x .
PMID
11460491 .
S2CID
25431334 .
Plow EF, Cierniewski CS, Xiao Z, et al. (2002). "AlphaIIbbeta3 and its antagonism at the new millennium". Thromb. Haemost . 86 (1): 34–40.
doi :
10.1055/s-0037-1616198 .
PMID
11487023 .
S2CID
74389210 .
Quinn MJ, Byzova TV, Qin J, et al. (2004).
"Integrin alphaIIbbeta3 and its antagonism" . Arterioscler. Thromb. Vasc. Biol . 23 (6): 945–52.
doi :
10.1161/01.ATV.0000066686.46338.F1 .
PMID
12637342 .
Fullard JF (2004). "The role of the platelet glycoprotein IIb/IIIa in thrombosis and haemostasis". Curr. Pharm. Des . 10 (14): 1567–76.
doi :
10.2174/1381612043384682 .
PMID
15134555 .
Watson SP, Auger JM, McCarty OJ, Pearce AC (2005).
"GPVI and integrin alphaIIb beta3 signaling in platelets" . J. Thromb. Haemost . 3 (8): 1752–62.
doi :
10.1111/j.1538-7836.2005.01429.x .
PMID
16102042 .
S2CID
42666713 .
Bennett JS (2006).
"Structure and function of the platelet integrin alphaIIbbeta3" . J. Clin. Invest . 115 (12): 3363–9.
doi :
10.1172/JCI26989 .
PMC
1297263 .
PMID
16322781 .
Ma YQ, Qin J, Plow EF (2007). "Platelet integrin alpha(IIb)beta(3): activation mechanisms". J. Thromb. Haemost . 5 (7): 1345–52.
doi :
10.1111/j.1538-7836.2007.02537.x .
PMID
17635696 .
S2CID
12983526 .
External links
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