From Wikipedia, the free encyclopedia
Pharmaceutical drug
Lipegfilgrastim , sold under the
brand name Lonquex , is a medication used to reduce the duration of
neutropenia and the incidence of
febrile neutropenia in adults.
[1] It is given by
injection under the skin in the abdomen, upper arm or thigh.
[1]
The most common side effects include
nausea as well as
bone and
muscle pain .
[1]
Lipegfilgrastim is similar to
granulocyte colony stimulating factor (
G‑CSF ), a naturally occurring
protein in the body that stimulates the production of
white blood cells including
neutrophils in the
bone marrow .
[1] Lipegfilgrastim acts in the same way as G‑CSF, increasing the production of neutrophils and thereby helping to reduce the duration of neutropenia and the occurrence of
febrile neutropenia (a sign of infection) in people receiving
chemotherapy .
[1]
Lipegfilgrastim is a
filgrastim biosimilar.
[1] In lipegfilgrastim, the filgrastim has been '
pegylated ' (attached to
polyethylene glycol ).
[1] This slows down the medicine's removal from the body and allows the medicine to be given less often.
[1]
Lipegfilgrastim was authorized for medical use in the
European Union in July 2013.
[1]
Medical uses
Lipegfilgrastim is indicated for the reduction in the duration of
neutropenia and the incidence of
febrile neutropenia in adults treated with
cytotoxic chemotherapy for
malignancy (with the exception of
chronic myeloid leukaemia and
myelodysplastic syndromes ).
[1]
References
Further reading
Bond TC, Szabo E, Gabriel S, Klastersky J, Tomey O, Mueller U, et al. (September 2018).
"Meta-analysis and indirect treatment comparison of lipegfilgrastim with pegfilgrastim and filgrastim for the reduction of chemotherapy-induced neutropenia-related events" . J Oncol Pharm Pract . 24 (6): 412–423.
doi :
10.1177/1078155217714859 .
PMC
6094503 .
PMID
28614980 .
Guariglia R, Martorelli MC, Lerose R, Telesca D, Milella MR, Musto P (2016).
"Lipegfilgrastim in the management of chemotherapy-induced neutropenia of cancer patients" . Biologics: Targets and Therapy . 10 : 1–8.
doi :
10.2147/BTT.S58597 .
PMC
4730998 .
PMID
26858523 .
Zou L, Buchner A, Roberge M, Liu PM (2016).
"Immunogenicity Assessment of Lipegfilgrastim in Patients with Breast Cancer Receiving Chemotherapy" . J Immunol Res . 2016 : 9248061.
doi :
10.1155/2016/9248061 .
PMC
4935921 .
PMID
27419145 .
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