T-cell surface glycoprotein CD3 zeta chain also known as T-cell receptor T3 zeta chain or CD247 (Cluster of Differentiation 247) is a
protein that in humans is encoded by the CD247gene.[5]
Some older literature mention a similar protein called "CD3 eta" in
mice. It is now understood to be an isoform differing in the last exon.[6]
Genomics
The gene is located on the long arm of
chromosome 1 at location 1q22-q25 on the
Crick (negative) strand. The encoded protein is 164 amino acids long with a predicted weight of 18.696 kilo
Daltons.
Function
T-cell receptor zeta (ζ), together with T-cell receptor alpha/beta and gamma/delta heterodimers and
CD3-gamma, -delta, and -epsilon, forms the T-cell receptor-CD3 complex. The zeta chain plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. Low expression of the antigen results in impaired immune response. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.[7]
Greenway AL, Holloway G, McPhee DA, Ellis P, Cornall A, Lidman M (2004). "HIV-1 Nef control of cell signalling molecules: multiple strategies to promote virus replication". J. Biosci. 28 (3): 323–35.
doi:
10.1007/BF02970151.
PMID12734410.
S2CID33749514.
Overview of all the structural information available in the
PDB for
UniProt: P20963 (Human T-cell surface glycoprotein CD3 zeta chain (CD247)) at the
PDBe-KB.