From Wikipedia, the free encyclopedia
Protein-coding gene in the species Homo sapiens
Signal-regulatory protein gamma is a
protein that in humans is encoded by the SIRPG
gene .
[3]
[4]
[5] SIRPG has also recently been designated CD172G (
cluster of differentiation 172G).
The protein encoded by this gene is a member of the
signal-regulatory protein (SIRP) family, and also belongs to the
immunoglobulin superfamily . SIRP family members are
receptor-type transmembrane glycoproteins known to be involved in the negative regulation of receptor tyrosine kinase-coupled signaling processes. Alternatively spliced transcript variants encoding different isoforms have been described.
[5]
References
^
a
b
c
GRCh38: Ensembl release 89: ENSG00000089012 –
Ensembl , May 2017
^
"Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^ Ichigotani Y, Matsuda S, Machida K, Oshima K, Iwamoto T, Yamaki K, Hayakawa T, Hamaguchi M (Jan 2001).
"Molecular cloning of a novel human gene (SIRP-B2) which encodes a new member of the SIRP/SHPS-1 protein family" . J Hum Genet . 45 (6): 378–82.
doi :
10.1007/s100380070013 .
PMID
11185750 .
^ van den Berg TK, van Beek EM, Buhring HJ, Colonna M, Hamaguchi M, Howard CJ, Kasuga M, Liu Y, Matozaki T, Neel BG, Parkos CA, Sano S, Vignery A, Vivier E, Wright M, Zawatzky R, Barclay AN (Dec 2005).
"A nomenclature for signal regulatory protein family members" . J Immunol . 175 (12): 7788–9.
doi :
10.4049/jimmunol.175.12.7788 .
PMID
16339511 .
^
a
b
"Entrez Gene: SIRPG signal-regulatory protein gamma" .
Further reading
Kharitonenkov A, Chen Z, Sures I, et al. (1997). "A family of proteins that inhibit signalling through tyrosine kinase receptors". Nature . 386 (6621): 181–6.
Bibcode :
1997Natur.386..181K .
doi :
10.1038/386181a0 .
PMID
9062191 .
S2CID
4259314 .
Deloukas P, Matthews LH, Ashurst J, et al. (2002).
"The DNA sequence and comparative analysis of human chromosome 20" . Nature . 414 (6866): 865–71.
Bibcode :
2001Natur.414..865D .
doi :
10.1038/414865a .
PMID
11780052 .
Strausberg RL, Feingold EA, Grouse LH, et al. (2003).
"Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899–903.
Bibcode :
2002PNAS...9916899M .
doi :
10.1073/pnas.242603899 .
PMC
139241 .
PMID
12477932 .
Brooke G, Holbrook JD, Brown MH, Barclay AN (2004).
"Human lymphocytes interact directly with CD47 through a novel member of the signal regulatory protein (SIRP) family" . J. Immunol . 173 (4): 2562–70.
doi :
10.4049/jimmunol.173.4.2562 .
PMID
15294972 .
Piccio L, Vermi W, Boles KS, et al. (2006).
"Adhesion of human T cells to antigen-presenting cells through SIRPbeta2-CD47 interaction costimulates T-cell proliferation" . Blood . 105 (6): 2421–7.
doi :
10.1182/blood-2004-07-2823 .
PMID
15383453 .
Gerhard DS, Wagner L, Feingold EA, et al. (2004).
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)" . Genome Res . 14 (10B): 2121–7.
doi :
10.1101/gr.2596504 .
PMC
528928 .
PMID
15489334 .
Kimura K, Wakamatsu A, Suzuki Y, et al. (2006).
"Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes" . Genome Res . 16 (1): 55–65.
doi :
10.1101/gr.4039406 .
PMC
1356129 .
PMID
16344560 .
External links
PDBe-KB provides an overview of all the structure information available in the PDB for Human Signal-regulatory protein gamma (SIRPG)
This article incorporates text from the
United States National Library of Medicine , which is in the
public domain .
1–50 51–100 101–150 151–200 201–250 251–300 301–350