From Wikipedia, the free encyclopedia
Protein-coding gene in the species Homo sapiens
Interferon gamma receptor 2 also known as IFN-γR2 is a
protein which in humans is encoded by the IFNGR2
gene .
[5]
Function
This gene (IFNGR2 ) encodes the non-ligand-binding beta chain of the
gamma interferon receptor . Human interferon-gamma receptor is a multimer of two IFN-γR1 chains (encoded by
IFNGR1 ) and two IFN-γR2 chains.
[6]
Clinical significance
Defects in IFNGR2 are a cause of
autosomal recessive
mendelian susceptibility to mycobacterial disease (MSMD), also known as familial disseminated atypical mycobacterial infection.
[7]
All known mutations in IFNGR2 are collected in the IFNGR2 mutation database.
[8]
References
^
a
b
c
ENSG00000262795 GRCh38: Ensembl release 89: ENSG00000159128, ENSG00000262795 –
Ensembl , May 2017
^
a
b
c
GRCm38: Ensembl release 89: ENSMUSG00000022965 –
Ensembl , May 2017
^
"Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^
"Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^ Luster AD, Weinshank RL, Feinman R, Ravetch JV (August 1988).
"Molecular and biochemical characterization of a novel gamma-interferon-inducible protein" . J. Biol. Chem . 263 (24): 12036–43.
doi :
10.1016/S0021-9258(18)37889-X .
PMID
3136170 . [
permanent dead link ]
^
"Entrez Gene: IFNGR2" .
^ Al-Muhsen S, Casanova JL (December 2008).
"The genetic heterogeneity of mendelian susceptibility to mycobacterial diseases" . J. Allergy Clin. Immunol . 122 (6): 1043–51, quiz 1052–3.
doi :
10.1016/j.jaci.2008.10.037 .
PMID
19084105 .
^
"All genes - Global Variome shared LOVD" .
This article incorporates text from the
United States National Library of Medicine , which is in the
public domain .
Chemokine
CSF
Interferon
IFNAR (α/β, I)
Agonists:
Albinterferon
Interferon alpha (interferon alfa, IFN-α)
Interferon alfa (
IFNA1 ,
IFNA2 ,
IFNA4 ,
IFNA5 ,
IFNA6 ,
IFNA7 ,
IFNA8 ,
IFNA10 ,
IFNA13 ,
IFNA14 ,
IFNA16 ,
IFNA17 ,
IFNA21 )
Interferon alfa 2a
Interferon alfa 2b
Interferon alfa n1
Interferon alfacon-1
Interferon alpha-n3
Interferon beta (IFN-β) (
IFNB1 ,
IFNB3 )
Interferon beta 1a
Interferon beta 1b
Interferon kappa (IFN-ε/κ/τ/ζ, IFNK)
Interferon omega (IFN-ω, IFNW1)
Peginterferon alfa-2a
Peginterferon alfa-2b
IFNGR (γ, II)
IFNLR (λ, III)
See IL-28R (IFNLR)
here instead.
Interleukin
TGFβ
TNF Others