From Wikipedia, the free encyclopedia
Protein-coding gene in the species Homo sapiens
Junctional adhesion molecule B is a
protein that in humans is encoded by the JAM2
gene .
[5]
[6]
[7] JAM2 has also been designated as CD322 (
cluster of differentiation 322).
Function
Tight junctions represent one mode of cell-to-cell adhesion in
endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the
paracellular space . The protein encoded by this
immunoglobulin superfamily gene member is localized in the tight junctions between
high endothelial cells . It acts as an adhesive ligand for interacting with a variety of
immune cell types and may play a role in
lymphocyte
homing to secondary
lymphoid organs .
[7]
It is purported to promote lymphocyte transendothelial migration.
[8] It might also be involved with endothelial
cell polarity , by associating to cell polarity protein
PARD3 (PAR-3), together with
JAM3 .
[9]
Interactions
JAM2 has been shown to
interact with
PARD3 .
[9]
It also interacts with the
integrin dimer
VLA-4 (also called α4β1).
[10]
References
^
a
b
c
GRCh38: Ensembl release 89: ENSG00000154721 –
Ensembl , May 2017
^
a
b
c
GRCm38: Ensembl release 89: ENSMUSG00000053062 –
Ensembl , May 2017
^
"Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^
"Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^ Palmeri D, van Zante A, Huang CC, Hemmerich S, Rosen SD (Aug 2000).
"Vascular endothelial junction-associated molecule, a novel member of the immunoglobulin superfamily, is localized to intercellular boundaries of endothelial cells" . J Biol Chem . 275 (25): 19139–45.
doi :
10.1074/jbc.M003189200 .
PMID
10779521 .
^ Cunningham SA, Arrate MP, Rodriguez JM, Bjercke RJ, Vanderslice P, Morris AP, Brock TA (Nov 2000).
"A novel protein with homology to the junctional adhesion molecule. Characterization of leukocyte interactions" . J Biol Chem . 275 (44): 34750–6.
doi :
10.1074/jbc.M002718200 .
PMID
10945976 .
^
a
b
"Entrez Gene: JAM2 junctional adhesion molecule 2" .
^ Johnson-Léger CA, Aurrand-Lions M, Beltraminelli N, Fasel N, Imhof BA (October 2002).
"Junctional adhesion molecule-2 (JAM-2) promotes lymphocyte transendothelial migration" . Blood . 100 (7): 2479–86.
doi :
10.1182/blood-2001-11-0098 .
PMID
12239159 .
^
a
b Ebnet K, Aurrand-Lions M, Kuhn A, Kiefer F, Butz S, Zander K, Meyer zu Brickwedde MK, Suzuki A, Imhof BA, Vestweber D (October 2003).
"The junctional adhesion molecule (JAM) family members JAM-2 and JAM-3 associate with the cell polarity protein PAR-3: a possible role for JAMs in endothelial cell polarity" . J. Cell Sci . 116 (Pt 19): 3879–91.
doi :
10.1242/jcs.00704 .
PMID
12953056 .
^ Cunningham SA, Rodriguez JM, Arrate MP, Tran TM, Brock TA (August 2002).
"JAM2 interacts with alpha4beta1. Facilitation by JAM3" . J. Biol. Chem . 277 (31): 27589–92.
doi :
10.1074/jbc.C200331200 .
PMID
12070135 .
Further reading
Muller WA (2003). "Leukocyte-endothelial-cell interactions in leukocyte transmigration and the inflammatory response". Trends Immunol . 24 (6): 327–34.
doi :
10.1016/S1471-4906(03)00117-0 .
PMID
12810109 .
Bazzoni G (2004). "The JAM family of junctional adhesion molecules". Curr. Opin. Cell Biol . 15 (5): 525–30.
doi :
10.1016/S0955-0674(03)00104-2 .
PMID
14519386 .
Hattori M, Fujiyama A, Taylor TD, et al. (2000).
"The DNA sequence of human chromosome 21" . Nature . 405 (6784): 311–9.
Bibcode :
2000Natur.405..311H .
doi :
10.1038/35012518 .
PMID
10830953 .
Hartley JL, Temple GF, Brasch MA (2001).
"DNA cloning using in vitro site-specific recombination" . Genome Res . 10 (11): 1788–95.
doi :
10.1101/gr.143000 .
PMC
310948 .
PMID
11076863 .
Arrate MP, Rodriguez JM, Tran TM, et al. (2002).
"Cloning of human junctional adhesion molecule 3 (JAM3) and its identification as the JAM2 counter-receptor" . J. Biol. Chem . 276 (49): 45826–32.
doi :
10.1074/jbc.M105972200 .
PMID
11590146 .
Liang TW, Chiu HH, Gurney A, et al. (2002).
"Vascular endothelial-junctional adhesion molecule (VE-JAM)/JAM 2 interacts with T, NK, and dendritic cells through JAM 3" . J. Immunol . 168 (4): 1618–26.
doi :
10.4049/jimmunol.168.4.1618 .
PMID
11823489 .
Gardiner K, Slavov D, Bechtel L, Davisson M (2002). "Annotation of human chromosome 21 for relevance to Down syndrome: gene structure and expression analysis". Genomics . 79 (6): 833–43.
doi :
10.1006/geno.2002.6782 .
PMID
12036298 .
Cunningham SA, Rodriguez JM, Arrate MP, et al. (2002).
"JAM2 interacts with alpha4beta1. Facilitation by JAM3" . J. Biol. Chem . 277 (31): 27589–92.
doi :
10.1074/jbc.C200331200 .
PMID
12070135 .
Aurrand-Lions M, Johnson-Leger C, Lamagna C, et al. (2004). "Junctional adhesion molecules and interendothelial junctions". Cells Tissues Organs (Print) . 172 (3): 152–60.
doi :
10.1159/000066967 .
PMID
12476045 .
S2CID
34211576 .
Strausberg RL, Feingold EA, Grouse LH, et al. (2003).
"Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899–903.
Bibcode :
2002PNAS...9916899M .
doi :
10.1073/pnas.242603899 .
PMC
139241 .
PMID
12477932 .
Ebnet K, Aurrand-Lions M, Kuhn A, et al. (2004).
"The junctional adhesion molecule (JAM) family members JAM-2 and JAM-3 associate with the cell polarity protein PAR-3: a possible role for JAMs in endothelial cell polarity" . J. Cell Sci . 116 (Pt 19): 3879–91.
doi :
10.1242/jcs.00704 .
PMID
12953056 .
Clark HF, Gurney AL, Abaya E, et al. (2003).
"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment" . Genome Res . 13 (10): 2265–70.
doi :
10.1101/gr.1293003 .
PMC
403697 .
PMID
12975309 .
Zhang Z, Henzel WJ (2005).
"Signal peptide prediction based on analysis of experimentally verified cleavage sites" . Protein Sci . 13 (10): 2819–24.
doi :
10.1110/ps.04682504 .
PMC
2286551 .
PMID
15340161 .
Gerhard DS, Wagner L, Feingold EA, et al. (2004).
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)" . Genome Res . 14 (10B): 2121–7.
doi :
10.1101/gr.2596504 .
PMC
528928 .
PMID
15489334 .
Wiemann S, Arlt D, Huber W, et al. (2004).
"From ORFeome to biology: a functional genomics pipeline" . Genome Res . 14 (10B): 2136–44.
doi :
10.1101/gr.2576704 .
PMC
528930 .
PMID
15489336 .
Liu T, Qian WJ, Gritsenko MA, et al. (2006).
"Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry" . J. Proteome Res . 4 (6): 2070–80.
doi :
10.1021/pr0502065 .
PMC
1850943 .
PMID
16335952 .
External links
This article incorporates text from the
United States National Library of Medicine , which is in the
public domain .
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