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Latrophilin receptor)
| Latrophilin | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| Symbol | Latrophilin | ||||||||
| Pfam | PF02354 | ||||||||
| InterPro | IPR003334 | ||||||||
| |||||||||
| EGF, latrophilin and seven transmembrane domain containing 1 | |||||||
|---|---|---|---|---|---|---|---|
| Identifiers | |||||||
| Symbol | ELTD1 | ||||||
| Alt. symbols | ETL | ||||||
| NCBI gene | 64123 | ||||||
| HGNC | 20822 | ||||||
| RefSeq | NM_022159 | ||||||
| UniProt | Q9HBW9 | ||||||
| Other data | |||||||
| Locus | Chr. 1 p33-p32 | ||||||
| |||||||
| latrophilin 1 | |||||||
|---|---|---|---|---|---|---|---|
| Identifiers | |||||||
| Symbol | LPHN1 | ||||||
| Alt. symbols | KIAA0821, CIRL1, LEC2 | ||||||
| NCBI gene | 22859 | ||||||
| HGNC | 20973 | ||||||
| RefSeq | NM_014921 | ||||||
| UniProt | O94910 | ||||||
| Other data | |||||||
| Locus | Chr. 19 p13.2 | ||||||
| |||||||
| latrophilin 2 | |||||||
|---|---|---|---|---|---|---|---|
| Identifiers | |||||||
| Symbol | LPHN2 | ||||||
| Alt. symbols | LPHH1, KIAA0786, LEC1 | ||||||
| NCBI gene | 23266 | ||||||
| HGNC | 18582 | ||||||
| OMIM | 607018 | ||||||
| RefSeq | NM_012302 | ||||||
| UniProt | O95490 | ||||||
| Other data | |||||||
| Locus | Chr. 1 p31.1 | ||||||
| |||||||
| latrophilin 3 | |||||||
|---|---|---|---|---|---|---|---|
| Identifiers | |||||||
| Symbol | LPHN3 | ||||||
| Alt. symbols | KIAA0768, LEC3 | ||||||
| NCBI gene | 23284 | ||||||
| HGNC | 20974 | ||||||
| RefSeq | NM_015236 | ||||||
| UniProt | Q9HAR2 | ||||||
| Other data | |||||||
| Locus | Chr. 4 q13.1 | ||||||
| |||||||
Latrophilins are a group of highly conserved G-protein coupled receptors from the adhesion G protein-coupled receptor family. These receptors were originally identified based on their ability to bind to a component of black widow spider venom known as alpha-latrotoxin. [1] This conserved family of membrane proteins has up to three homologues in chordate species, including humans. [2]
The precise functions of latrophilins remain unknown. [2] Genetic defects in latrophilin genes have been associated with diseases such as attention-deficit hyperactivity disorder and cancer. [3]
Human proteins containing this domain
See also
References
- ^ Kreienkamp HJ, Soltau M, Richter D, Böckers T (2002). "Interaction of G-protein-coupled receptors with synaptic scaffolding proteins". Biochem. Soc. Trans. 30 (4): 464–8. doi: 10.1042/BST0300464. PMID 12196116.
- ^ a b Silva, JP; Ushkaryov, YA (2010). "The Latrophilins, "Split-Personality" Receptors". Adhesion-GPCRS. Advances in Experimental Medicine and Biology. Vol. 706. pp. 59–75. doi: 10.1007/978-1-4419-7913-1_5. ISBN 978-1-4419-7912-4. PMC 3145135. PMID 21618826.
- ^ Meza-Aguilar, Diana G; Boucard, Antony A (1 January 2014). "Latrophilins updated". Biomolecular Concepts. 5 (6): 457–478. doi: 10.1515/bmc-2014-0032. PMID 25429599. S2CID 207442054.