Metabotropic glutamate receptor 8 is a
protein that in humans is encoded by the GRM8gene.[5][6]
Function
L-glutamate is the major
excitatory neurotransmitter in the
central nervous system and activates both
ionotropic and
metabotropic glutamate receptors.
Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many
neuropathologic conditions. The metabotropic glutamate receptors are a family of
G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes
GRM1 and
GRM5 and these receptors have been shown to activate phospholipase C. Group II includes
GRM2 and
GRM3 while Group III includes
GRM4,
GRM6,
GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the
cyclic AMP cascade but differ in their agonist selectivities. Alternative
splice variants of GRM8 have been described but their full-length nature has not been determined.[6]
Wu S, Wright RA, Rockey PK, Burgett SG, Arnold JS, Rosteck PR, et al. (January 1998). "Group III human metabotropic glutamate receptors 4, 7 and 8: molecular cloning, functional expression, and comparison of pharmacological properties in RGT cells". Brain Research. Molecular Brain Research. 53 (1–2): 88–97.
doi:
10.1016/S0169-328X(97)00277-5.
PMID9473604.
Malherbe P, Kratzeisen C, Lundstrom K, Richards JG, Faull RL, Mutel V (April 1999). "Cloning and functional expression of alternative spliced variants of the human metabotropic glutamate receptor 8". Brain Research. Molecular Brain Research. 67 (2): 201–210.
doi:
10.1016/S0169-328X(99)00050-9.
PMID10216218.
Thomas NK, Wright RA, Howson PA, Kingston AE, Schoepp DD, Jane DE (March 2001). "(S)-3,4-DCPG, a potent and selective mGlu8a receptor agonist, activates metabotropic glutamate receptors on primary afferent terminals in the neonatal rat spinal cord". Neuropharmacology. 40 (3): 311–318.
doi:
10.1016/S0028-3908(00)00169-6.
PMID11166323.
S2CID2872874.