Neuropeptide_Y_receptor_Y5 References

NPY5R
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2HE6
Identifiers
Aliases	NPY5R, NPY5-R, NPYR5, NPYY5-R, Neuropeptide Y receptor Y5
External IDs	OMIM: 602001 MGI: 108082 HomoloGene: 21241 GeneCards: NPY5R
Gene location ( Human)
Chr.	Chromosome 4 (human)
End	163,351,934 bp
Gene location ( Mouse)
Chr.	Chromosome 8 (mouse)
End	67,140,780 bp
RNA expression pattern
	Top expressed in
	adipose tissue; ; spleen; ; subcutaneous adipose tissue; ; prefrontal cortex; ; abdominal fat; ; nucleus accumbens; ; ascending aorta; ; right coronary artery; ; caudate nucleus; ; dorsolateral prefrontal cortex;
	Top expressed in
	suprachiasmatic nucleus; ; substantia nigra; ; Region I of hippocampus proper; ; neuron; ; facial motor nucleus; ; nucleus accumbens; ; arcuate nucleus; ; superior frontal gyrus; ; hippocampus proper; ; trigeminal ganglion;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	neuropeptide Y receptor activity; G protein-coupled receptor activity; signal transducer activity; peptide YY receptor activity; pancreatic polypeptide receptor activity;
Cellular component	cytoplasm; integral component of membrane; membrane; plasma membrane; integral component of plasma membrane; neuron projection;
Biological process	G protein-coupled receptor signaling pathway; negative regulation of glutamate secretion; eating behavior; outflow tract morphogenesis; negative regulation of apoptotic process; cardiac left ventricle morphogenesis; negative regulation of synaptic transmission, GABAergic; feeding behavior; positive regulation of acute inflammatory response; generation of ovulation cycle rhythm; neuropeptide signaling pathway; signal transduction; positive regulation of smooth muscle cell proliferation; positive regulation of cell population proliferation; human ageing; chemical synaptic transmission; negative regulation of acute inflammatory response to antigenic stimulus; positive regulation of ERK1 and ERK2 cascade; blood circulation;
	Sources: Amigo / QuickGO
Orthologs
	4889
	18168
	ENSG00000164129
	ENSMUSG00000044014
	Q15761
	O70342
	NM_006174; NM_001317091; NM_001317092
	NM_016708; NM_001358957; NM_001358958
	NP_001304020; NP_001304021; NP_006165
	NP_057917; NP_001345886; NP_001345887
	Wikidata
View/Edit Human	View/Edit Mouse

Neuropeptide Y receptor type 5 is a protein that in humans is encoded by the NPY5R gene.^[5]^[6]^[7]

Selective ligands

Agonists

Neuropeptide Y (endogenous agonist, non subtype selective)
BWX-46 (selective NPY₅ agonist, CAS# 172997-92-1)
Peptide YY

Antagonists

CGP-71683 (CAS# 192322-50-2)
FMS-586^[8]
L-152,804 (CAS# 6508-43-6)
Lu AA-33810^[9]
MK-0557^[10]
NTNCB (CAS# 486453-65-0)^[11]
Velneperit (S-2367)

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000164129 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000044014 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Gerald C, Walker MW, Criscione L, Gustafson EL, Batzl-Hartmann C, Smith KE, Vaysse P, Durkin MM, Laz TM, Linemeyer DL, Schaffhauser AO, Whitebread S, Hofbauer KG, Taber RI, Branchek TA, Weinshank RL (Jul 1996). "A receptor subtype involved in neuropeptide-Y-induced food intake". Nature. 382 (6587): 168–71. Bibcode: 1996Natur.382..168G. doi: 10.1038/382168a0. PMID 8700207. S2CID 4286144.
^ Lutz CM, Richards JE, Scott KL, Sinha S, Yang-Feng TL, Frankel WN, Thompson DA (Dec 1997). "Neuropeptide Y receptor genes mapped in human and mouse: receptors with high affinity for pancreatic polypeptide are not clustered with receptors specific for neuropeptide Y and peptide YY". Genomics. 46 (2): 287–90. doi: 10.1006/geno.1997.5024. PMID 9417917.
^ "Entrez Gene: NPY5R neuropeptide Y receptor Y5".
^ Kakui N, Tanaka J, Tabata Y, Asai K, Masuda N, Miyara T, Nakatani Y, Ohsawa F, Nishikawa N, Sugai M, Suzuki M, Aoki K, Kitaguchi H (May 2006). "Pharmacological characterization and feeding-suppressive property of FMS586 [3-(5,6,7,8-tetrahydro-9-isopropyl-carbazol-3-yl)-1-methyl-1-(2-pyridin-4-yl-ethyl)-urea hydrochloride], a novel, selective, and orally active antagonist for neuropeptide Y Y5 receptor". The Journal of Pharmacology and Experimental Therapeutics. 317 (2): 562–70. doi: 10.1124/jpet.105.099705. PMID 16436501. S2CID 6064389.
^ Walker MW, Wolinsky TD, Jubian V, Chandrasena G, Zhong H, Huang X, Miller S, Hegde LG, Marsteller DA, Marzabadi MR, Papp M, Overstreet DH, Gerald CP, Craig DA (Mar 2009). "The novel neuropeptide Y Y5 receptor antagonist Lu AA33810 [N-[[trans-4-[(4,5-dihydro[1]benzothiepino[5,4-d]thiazol-2-yl)amino]cyclohexyl]methyl]-methanesulfonamide] exerts anxiolytic- and antidepressant-like effects in rat models of stress sensitivity". The Journal of Pharmacology and Experimental Therapeutics. 328 (3): 900–11. doi: 10.1124/jpet.108.144634. PMID 19098165. S2CID 20295744.
^ MacNeil DJ (2007). "NPY Y1 and Y5 receptor selective antagonists as anti-obesity drugs". Current Topics in Medicinal Chemistry. 7 (17): 1721–33. doi: 10.2174/156802607782341028. PMID 17979781. Archived from the original on 2013-01-12. Retrieved 2020-04-16.
^ Islam I, Dhanoa D, Finn J, Du P, Walker MW, Salon JA, Zhang J, Gluchowski C (Jul 2002). "Discovery of potent and selective small molecule NPY Y5 receptor antagonists". Bioorganic & Medicinal Chemistry Letters. 12 (13): 1767–9. doi: 10.1016/S0960-894X(02)00287-1. PMID 12067557.

External links

"Neuropeptide Y Receptors: Y₅". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology.

This transmembrane receptor-related article is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000164129 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000044014 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8700207-5] Gerald C, Walker MW, Criscione L, Gustafson EL, Batzl-Hartmann C, Smith KE, Vaysse P, Durkin MM, Laz TM, Linemeyer DL, Schaffhauser AO, Whitebread S, Hofbauer KG, Taber RI, Branchek TA, Weinshank RL (Jul 1996). "A receptor subtype involved in neuropeptide-Y-induced food intake". Nature. 382 (6587): 168–71. Bibcode: 1996Natur.382..168G. doi: 10.1038/382168a0. PMID 8700207. S2CID 4286144.

[pmid9417917-6] Lutz CM, Richards JE, Scott KL, Sinha S, Yang-Feng TL, Frankel WN, Thompson DA (Dec 1997). "Neuropeptide Y receptor genes mapped in human and mouse: receptors with high affinity for pancreatic polypeptide are not clustered with receptors specific for neuropeptide Y and peptide YY". Genomics. 46 (2): 287–90. doi: 10.1006/geno.1997.5024. PMID 9417917.

[entrez-7] "Entrez Gene: NPY5R neuropeptide Y receptor Y5".

[pmid16436501-8] Kakui N, Tanaka J, Tabata Y, Asai K, Masuda N, Miyara T, Nakatani Y, Ohsawa F, Nishikawa N, Sugai M, Suzuki M, Aoki K, Kitaguchi H (May 2006). "Pharmacological characterization and feeding-suppressive property of FMS586 [3-(5,6,7,8-tetrahydro-9-isopropyl-carbazol-3-yl)-1-methyl-1-(2-pyridin-4-yl-ethyl)-urea hydrochloride], a novel, selective, and orally active antagonist for neuropeptide Y Y5 receptor". The Journal of Pharmacology and Experimental Therapeutics. 317 (2): 562–70. doi: 10.1124/jpet.105.099705. PMID 16436501. S2CID 6064389.

[pmid19098165-9] Walker MW, Wolinsky TD, Jubian V, Chandrasena G, Zhong H, Huang X, Miller S, Hegde LG, Marsteller DA, Marzabadi MR, Papp M, Overstreet DH, Gerald CP, Craig DA (Mar 2009). "The novel neuropeptide Y Y5 receptor antagonist Lu AA33810 [N-[[trans-4-[(4,5-dihydro[1]benzothiepino[5,4-d]thiazol-2-yl)amino]cyclohexyl]methyl]-methanesulfonamide] exerts anxiolytic- and antidepressant-like effects in rat models of stress sensitivity". The Journal of Pharmacology and Experimental Therapeutics. 328 (3): 900–11. doi: 10.1124/jpet.108.144634. PMID 19098165. S2CID 20295744.

[pmid17979781-10] MacNeil DJ (2007). "NPY Y1 and Y5 receptor selective antagonists as anti-obesity drugs". Current Topics in Medicinal Chemistry. 7 (17): 1721–33. doi: 10.2174/156802607782341028. PMID 17979781. Archived from the original on 2013-01-12. Retrieved 2020-04-16.

[pmid12067557-11] Islam I, Dhanoa D, Finn J, Du P, Walker MW, Salon JA, Zhang J, Gluchowski C (Jul 2002). "Discovery of potent and selective small molecule NPY Y5 receptor antagonists". Bioorganic & Medicinal Chemistry Letters. 12 (13): 1767–9. doi: 10.1016/S0960-894X(02)00287-1. PMID 12067557.

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Selective ligands

Agonists

Antagonists

See also

References

Further reading

External links