From Wikipedia, the free encyclopedia
G-protein coupled receptor
Cholecystokinin receptors or CCK receptors are a group of
G-protein coupled receptors which bind the peptide hormones
cholecystokinin (CCK) and
gastrin .
[1] There are two different subtypes
CCKA and
CCKB which are ~50%
homologous :
[2] Various
cholecystokinin antagonists have been developed and are used in research, although the only drug of this class that has been widely marketed to date is the anti-ulcer drug
proglumide .
Protein
Gene
Tissue distribution
Preferred ligand
Function
Mechanism
CCKA (CCK1 )
CCKAR
primarily
gastrointestinal tract , lesser amounts in the
CNS
sulfated CCK >> nonsulfated CCK ≈ nonsulfated CCK
stimulation of bicarb secretion, gall bladder emptying and inhibiting gut motility
Gq
[3]
[4]
CCKB (CCK2 )
CCKBR
primarily CNS, lesser amounts in the gastrointestinal tract
gastrin ≈ CCK (receptor does not discriminate between sulfated and nonsulfated peptides)
regulation of
nociception ,
anxiety ,
memory and
hunger
Gq /G11
[4]
References
^ Noble F, Wank SA,
Crawley JN , Bradwejn J, Seroogy KB, Hamon M, Roques BP (December 1999).
"International Union of Pharmacology. XXI. Structure, distribution, and functions of cholecystokinin receptors" . Pharmacological Reviews . 51 (4): 745–781.
PMID
10581329 .
^ Dufresne M, Seva C, Fourmy D (July 2006). "Cholecystokinin and gastrin receptors". Physiological Reviews . 86 (3): 805–847.
doi :
10.1152/physrev.00014.2005 .
PMID
16816139 .
^ Wank SA (April 1998). "G protein-coupled receptors in gastrointestinal physiology. I. CCK receptors: an exemplary family". The American Journal of Physiology . 274 (4 Pt 1): G607–G613.
doi :
10.1152/ajpgi.1998.274.4.g607 .
PMID
9575840 .
S2CID
27674659 . ^
a b Beinfeld M, Chen Q, Gao F, Liddle RA, Miller LJ, Rehfeld J (2019-09-16).
"Cholecystokinin receptors (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database" . IUPHAR/BPS Guide to Pharmacology CITE . 2019 (4).
doi :
10.2218/gtopdb/F15/2019.4 .
S2CID
203825385 .
External links
