From Wikipedia, the free encyclopedia
Chemical compound
Acotiamide
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Trade names | Acofide |
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Other names | YM-443, Z-338 |
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Routes of administration |
By mouth |
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ATC code | |
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Legal status |
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Protein binding | 84.21–85.95% |
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Metabolism |
UGT1A8 and
1A9 (major) |
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Elimination half-life | 10.9–21.7 hours |
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Excretion | Feces (92.7%), urine (5.3%)
[1] |
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N-{2-[bis(1-Methylethyl)amino]ethyl}-2-{[(2-hydroxy-4,5-dimethoxyphenyl)carbonyl]amino}-1,3-thiazole-4-carboxamide
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CAS Number | |
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PubChem
CID | |
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ChemSpider | |
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KEGG | |
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ChEMBL | |
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Formula | C21H30N4O5S |
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Molar mass | 450.55 g·mol−1 |
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3D model (
JSmol) | |
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O=C(Nc1nc(C(=O)NCCN(C(C)C)C(C)C)cs1)c2cc(OC)c(OC)cc2O
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InChI=1S/C21H30N4O5S/c1-12(2)25(13(3)4)8-7-22-20(28)15-11-31-21(23-15)24-19(27)14-9-17(29-5)18(30-6)10-16(14)26/h9-13,26H,7-8H2,1-6H3,(H,22,28)(H,23,24,27) YKey:TWHZNAUBXFZMCA-UHFFFAOYSA-N Y
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NY
(what is this?)
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Acotiamide, sold under the brand name Acofide,
[2]
[3] is a
medication manufactured and approved in Japan for the treatment of
postprandial fullness, upper abdominal
bloating, and early
satiation due to
functional dyspepsia.
[4] It acts as an
acetylcholinesterase inhibitor.
References
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^
"Acofide (acotiamide hydrochloride hydrate) Tablets Review Report" (PDF). Retrieved 29 December 2016.
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^ Nowlan ML, Scott LJ (August 2013). "Acotiamide: first global approval". Drugs. 73 (12): 1377–83.
doi:
10.1007/s40265-013-0100-9.
PMID
23881665.
S2CID
20383853.
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^ Matsunaga Y, Tanaka T, Saito Y, Kato H, Takei M (February 2014).
"[Pharmacological and clinical profile of acotiamide hydrochloride hydrate (Acofide(®) Tablets 100 mg), a novel therapeutic agent for functional dyspepsia (FD)]". Nihon Yakurigaku Zasshi. Folia Pharmacologica Japonica (in Japanese). 143 (2): 84–94.
doi:
10.1254/fpj.143.84.
PMID
24531902.
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^ Matsueda K, Hongo M, Tack J, Aoki H, Saito Y, Kato H (June 2010). "Clinical trial: dose-dependent therapeutic efficacy of acotiamide hydrochloride (Z-338) in patients with functional dyspepsia - 100 mg t.i.d. is an optimal dosage". Neurogastroenterology and Motility. 22 (6): 618–e173.
doi:
10.1111/j.1365-2982.2009.01449.x.
PMID
20059698.
S2CID
41298446.