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MSPI
Names
Other names
MSMPID
Identifiers
3D model ( JSmol)
ChemSpider
PubChem CID
  • InChI=1S/C5H9N2O2PS/c1-6-3-4-7(5-6)10(8,9)11-2/h3-5H,1-2H3
    Key: QSLFDILMORXPKP-UHFFFAOYSA-N
  • C[N+]1=CN(C=C1)P(=O)([O-])SC
Properties
C5H9N2O2PS
Molar mass 192.17 g·mol−1
Hazards
Lethal dose or concentration (LD, LC):
LD50 ( median dose)
 3.15 mg/kg (mice, subcutaneous)
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).

MSPI is an irreversible acetylcholinesterase inhibitor. MSPI reacts with the acetylcholinesterase to form an aged enzyme adduct that can't be reactivated by cholinesterase reactivators. [1]

See also

References

  1. ^ Chabrier, P. E.; Jacob, J. (May 1980). "In vivo and in vitro inhibition of cholinesterase by methyl-1 (S methyl phosphoryl-3) imidazolium (MSPI), a model of an "instantly" aged phosphorylated enzyme". Archives of Toxicology. 45 (1): 15–20. doi: 10.1007/BF00303290. PMID  7396718. S2CID  24108114.


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