Trace amine-associated receptor 9 is a
protein that in humans is encoded by the TAAR9gene.[5][6]
TAAR9 is a member of a large family of
rhodopsinG protein–coupled receptors (GPCRs, or GPRs). GPCRs contain 7 transmembrane domains and transduce extracellular signals through
heterotrimeric G proteins.[supplied by OMIM][6] N-Methyl piperidine is a ligand of TAAR9 associated with aversive behavior in mice. N,N-dimethylcyclohexylamine is an additional binding agonist that also activaes TAAR7 variants.[7][8]
TAAR9 gene deletion in rats leads to significantly decreased low-density lipoprotein cholesterol levels in the blood.[9]
† References for all endogenous human TAAR1 ligands are provided at
List of trace amines
‡ References for synthetic TAAR1 agonists can be found at
TAAR1 or in the associated compound articles. For TAAR2 and TAAR5 agonists and inverse agonists, see
TAAR for references.