Clinical data | |
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Trade names | Humorsol |
Routes of administration | Topical ( ophthalmic solution) |
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ECHA InfoCard | 100.000.274 |
Chemical and physical data | |
Formula | C32H52Br2N4O4 |
Molar mass | 716.600 g·mol−1 |
3D model ( JSmol) | |
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Demecarium bromide, trade name Humorsol, is a carbamate parasympathomimetic drug that acts as an acetylcholinesterase inhibitor, and is used as a glaucoma medication. It is applied directly to the eye in order to reduce elevated intraocular pressure associated with glaucoma. [1]
Demecarium causes constriction of the pupil ( miosis), which improves the drainage of the fluid in the eye ( aqueous humour). [2] As demecarium reversibly inhibits cholinesterase, it can be administered less frequently than other parasympathomimetic drugs, such as carbachol. [3]
Commercially produced demecarium bromide solution, previously sold under the trade name Humorsol, [4] is no longer available, [3] although solutions of demecarium can be compounded. [5]
When administered with a topical corticosteroid, demecarium can delay the onset of primary glaucoma in dogs. [3] High doses of demecarium may cause organophosphate toxicity, particularly if flea treatments containing organophosphates are administered at the same time. [3]