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Pharmaceutical drug
Potassium canrenoate
Other names SC-14266
AHFS /
Drugs.com
International Drug Names
Routes of administration
Intravenous
ATC code
Metabolism
Hepatic
Excretion
Renal and fecal
potassium 3-[(8R ,9S ,10R ,13S ,14S ,17R )- 17-hydroxy-10,13-dimethyl-3-oxo-2,8,9, 11,12,14,15,16-octahydro-1H -cyclopenta[a] phenanthren-17-yl]propanoate
CAS Number
PubChem
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UNII
ChEMBL
CompTox Dashboard (
EPA )
ECHA InfoCard
100.016.868
Formula C 22 H 29 K O 4
Molar mass 396.568 g·mol−1 3D model (
JSmol )
[K+].[O-]C(=O)CC[C@]3(O)CC[C@H]2[C@@H]4/C=C\C1=C\C(=O)CC[C@@]1([C@H]4CC[C@@]23C)C
InChI=1S/C22H30O4.K/c1-20-9-5-15(23)13-14(20)3-4-16-17(20)6-10-21(2)18(16)7-11-22(21,26)12-8-19(24)25;/h3-4,13,16-18,26H,5-12H2,1-2H3,(H,24,25);/q;+1/p-1/t16-,17+,18+,20+,21+,22-;/m1./s1
Y Key:JTZQCHFUGHIPDF-RYVBEKKQSA-M
Y
N Y
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Potassium canrenoate (
INN ,
JAN ) or canrenoate potassium (
USAN ) (brand names Venactone , Soldactone ), also known as aldadiene kalium ,
[1] the
potassium
salt of
canrenoic acid , is an
aldosterone antagonist of the
spirolactone group.
[2] Like
spironolactone , it is a
prodrug , and is
metabolized to active
canrenone in the body.
[3]
[4]
Potassium canrenoate is notable in that it is the only clinically used antimineralocorticoid which is available for
parenteral
administration (specifically
intravenous )
[4]
[5] as opposed to
oral administration .
[6]
In the UK, it is unlicensed and only used for short term diuresis in oedema or heart failure in neonates or children under specialist initiation and monitoring.
See also
References
^ Selye H (17 April 2013).
Hormones and Resistance: Part 1 and . Springer Science & Business Media. pp. 186–.
ISBN
978-3-642-65192-2 .
^ Hill RA, Makin HL, Kirk DN, Murphy GM (23 May 1991).
Dictionary of Steroids . CRC Press. pp. 656–.
ISBN
978-0-412-27060-4 .
^ Burger A, Wolff ME (1996).
Burger's Medicinal Chemistry and Drug Discovery: Therapeutic agents . Wiley.
ISBN
978-0-471-57557-3 .
^
a
b Waldmann C, Soni N, Rhodes A (27 November 2008).
"Diurectics and the Critical Ill" . Oxford Desk Reference: Critical Care . OUP Oxford. pp. 187–.
ISBN
978-0-19-922958-1 .
^ Santambrogio R, Barabino M, Opocher E (21 June 2017).
"Non-resection: Radiofrequency Ablation, Cryo, Microwave" . In Bonjer HJ (ed.). Surgical Principles of Minimally Invasive Procedures: Manual of the European Association of Endoscopic Surgery (EAES) . Springer. pp. 136–.
ISBN
978-3-319-43196-3 .
^ Kolkhof P, Bärfacker L (July 2017).
"30 YEARS OF THE MINERALOCORTICOID RECEPTOR: Mineralocorticoid receptor antagonists: 60 years of research and development" . The Journal of Endocrinology . 234 (1): T125–T140.
doi :
10.1530/JOE-16-0600 .
PMC
5488394 .
PMID
28634268 .
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