From Wikipedia, the free encyclopedia
Chemical compound
PF-06260414
Legal status
6-[(4R)-4-methyl-1,1-dioxo-1,2,6-thiadiazinan-2-yl]isoquinoline-1-carbonitrile
CAS Number
PubChem
CID
DrugBank
ChemSpider
UNII
ChEMBL
Formula C 14 H 14 N 4 O 2 S
Molar mass 302.35 g·mol−1 3D model (
JSmol )
C[C@@H]1CNS(=O)(=O)N(C1)C2=CC3=C(C=C2)C(=NC=C3)C#N
InChI=1S/C14H14N4O2S/c1-10-8-17-21(19,20)18(9-10)12-2-3-13-11(6-12)4-5-16-14(13)7-15/h2-6,10,17H,8-9H2,1H3/t10-/m1/s1
Key:ZKAVFOXYJCREBQ-SNVBAGLBSA-N
PF-06260414 is a drug which acts as a
selective androgen receptor modulator (SARM), and was developed for androgen replacement therapy.
[1]
[2]
[3]
See also
References
^ Bhattacharya I, Tarabar S, Liang Y, Pradhan V, Owens J, Oemar B (June 2016). "Safety, Pharmacokinetic, and Pharmacodynamic Evaluation After Single and Multiple Ascending Doses of a Novel Selective Androgen Receptor Modulator in Healthy Subjects". Clinical Therapeutics . 38 (6): 1401–1416.
doi :
10.1016/j.clinthera.2016.03.025 .
PMID
27085586 .
^ Ventura E, Gadaj A, Buckley T, Mooney MH (September 2020).
"Development of a multi-residue high-throughput UHPLC-MS/MS method for routine monitoring of SARM compounds in equine and bovine blood" . Drug Testing and Analysis . 12 (9): 1373–1379.
doi :
10.1002/dta.2875 .
PMID
32519780 .
S2CID
219563612 .
^ Cutler C, Viljanto M, Taylor P, Hincks P, Biddle S, Van Eenoo P (October 2021).
"Identification of equine in vitro metabolites of seven non-steroidal selective androgen receptor modulators for doping control purposes" . Drug Testing and Analysis . 14 (2): 349–370.
doi :
10.1002/dta.3189 .
hdl :
1854/LU-8740373 .
PMID
34714606 .
S2CID
240152623 .
AR Tooltip Androgen receptor
Agonists
SARMs Tooltip Selective androgen receptor modulator Antagonists
GPRC6A