From Wikipedia, the free encyclopedia
Chemical compound
Bolasterone
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Trade names | Myagen, Methosarb |
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Other names | U-19763; NSC-66233; 7α,17α-Dimethyltestosterone; 7α,17α-Dimethylandrost-4-en-17β-ol-3-one |
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Routes of administration |
By mouth |
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Legal status |
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(7R,8R,9S,10R,13S,14S,17S)-17-hydroxy-7,10,13,17-tetramethyl-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthren-3-one
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CAS Number | |
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PubChem
CID | |
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ChemSpider | |
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UNII | |
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ChEMBL | |
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CompTox Dashboard (
EPA) | |
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ECHA InfoCard |
100.015.018
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Formula | C21H32O2 |
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Molar mass | 316.485 g·mol−1 |
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3D model (
JSmol) | |
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O=C4\C=C3/[C@]([C@H]2CC[C@]1([C@@H](CC[C@@]1(O)C)[C@@H]2[C@H](C)C3)C)(C)CC4
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InChI=1S/C21H32O2/c1-13-11-14-12-15(22)5-8-19(14,2)16-6-9-20(3)17(18(13)16)7-10-21(20,4)23/h12-13,16-18,23H,5-11H2,1-4H3/t13-,16+,17+,18-,19+,20+,21+/m1/s1 Key:IVFYLRMMHVYGJH-VLOLGRDOSA-N
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Bolasterone (
INNTooltip International Nonproprietary Name,
USANTooltip United States Adopted Name) (brand names Myagen, Methosarb; former developmental code name U-19763), also known as 7α,17α-dimethyltestosterone, is a
17α-alkylated
androgen/
anabolic steroid (AAS) which is used in
veterinary medicine.
[2]
[3] It has close structural similarity to
testosterone, and like
methyltestosterone has a
methyl group at C17α in order to increase
oral
bioavailability.
[2] In addition, it is also 7α-
methylated, similar to its 7β-methylated
isomer
calusterone.
[2] The medication has a low to moderate ratio of
anabolic to
androgenic activity, similar to that of
fluoxymesterone.
[4]
Bolasterone is on the
World Anti-Doping Agency's list of prohibited substances,
[5] and is therefore banned from use in most major sports.
References
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Androgens (incl.
AASTooltip anabolic–androgenic steroid) | |
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Antiandrogens |
ARTooltip Androgen receptor
antagonists | |
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Steroidogenesis inhibitors | |
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Antigonadotropins |
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D2 receptor
antagonists (
prolactin releasers) (e.g.,
domperidone,
metoclopramide,
risperidone,
haloperidol,
chlorpromazine,
sulpiride)
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Estrogens (e.g.,
bifluranol,
diethylstilbestrol,
estradiol,
estradiol esters,
ethinylestradiol,
ethinylestradiol sulfonate,
paroxypropione)
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GnRH agonists (e.g.,
leuprorelin)
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GnRH antagonists (e.g.,
cetrorelix)
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Progestogens (incl.,
chlormadinone acetate,
cyproterone acetate,
hydroxyprogesterone caproate,
gestonorone caproate,
medroxyprogesterone acetate,
megestrol acetate)
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Others | |
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ARTooltip Androgen receptor | Agonists | |
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SARMsTooltip Selective androgen receptor modulator | |
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Antagonists | |
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GPRC6A | |
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