Integrin alpha-10 also known as ITGA10 is a
protein that in humans is encoded by the ITGA10gene.[5][6][7]
Function
Integrins are
integral membrane proteins composed of an alpha chain and a beta chain, and are known to participate in
cell adhesion as well as cell-surface mediated signalling. The I-domain containing alpha 10 combines with the integrin beta 1 chain (
ITGB1) to form a novel
collagen type II-binding integrin expressed in
cartilage tissue.[5]
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doi:
10.1016/S0945-053X(01)00164-0.
PMID11731273.
Brakebusch C, Hirsch E, Potocnik A, Fässler R (1997). "Genetic analysis of beta1 integrin function: confirmed, new and revised roles for a crucial family of cell adhesion molecules". J. Cell Sci. 110 (23): 2895–904.
doi:
10.1242/jcs.110.23.2895.
PMID9359872.
Wenke AK, Rothhammer T, Moser M, Bosserhoff AK (2006). "Regulation of integrin alpha10 expression in chondrocytes by the transcription factors AP-2epsilon and Ets-1". Biochem. Biophys. Res. Commun. 345 (1): 495–501.
doi:
10.1016/j.bbrc.2006.04.123.
PMID16684505.