From Wikipedia, the free encyclopedia
αV β3 is a type of
integrin that is a
receptor for
vitronectin .
[1] It consists of two components,
integrin alpha V and
integrin beta 3 (
CD 61), and is expressed by
platelets . Furthermore, it is a receptor for
phagocytosis on
macrophages or
dendritic cells .
[2]
As a drug target
Integrin αV β3 is a potential drug target because abnormal expression of v3 is linked to the development and progression of various diseases. Its role in
angiogenesis , in cancer and other diseases, is linked to the blood supply for problematic overgrowths.
[3]
Inhibitors like
etaracizumab may be used as
antiangiogenics .
[4]
One novel protein (ProAgio) has been designed to bind at an unusual site, and then induces
apoptosis by recruiting
caspase 8 .
[3] It is designed by mutating domain 1 of
CD2 (D1-CD2), which naturally binds weakly to the receptor.
[5]
Fibronectin domain 10 contains the
RGD motif that αV β3 recognizes. A high-affinity, pure
antagonist mutant has been discovered for this protein.
[6]
See also
References
^ Hermann P, Armant M, Brown E, Rubio M, Ishihara H, Ulrich D, Caspary RG, Lindberg FP, Armitage R, Maliszewski C, Delespesse G, Sarfati M (February 1999).
"The vitronectin receptor and its associated CD47 molecule mediates proinflammatory cytokine synthesis in human monocytes by interaction with soluble CD23" . The Journal of Cell Biology . 144 (4): 767–75.
doi :
10.1083/jcb.144.4.767 .
PMC
2132927 .
PMID
10037797 .
^ Yamaguchi H, Takagi J, Miyamae T, Yokota S, Fujimoto T, Nakamura S, Ohshima S, Naka T, Nagata S (May 2008).
"Milk fat globule EGF factor 8 in the serum of human patients of systemic lupus erythematosus" . Journal of Leukocyte Biology . 83 (5): 1300–7.
doi :
10.1189/jlb.1107730 .
PMID
18303131 .
^
a
b
Novel Protein Agent Targets Cancer and Host of Other Diseases. June 2016
^ Santulli G, Basilicata MF, De Simone M, Del Giudice C, Anastasio A, Sorriento D, Saviano M, Del Gatto A, Trimarco B, Pedone C, Zaccaro L, Iaccarino G (January 2011).
"Evaluation of the anti-angiogenic properties of the new selective αVβ3 integrin antagonist RGDechiHCit" . Journal of Translational Medicine . 9 (1): 7.
doi :
10.1186/1479-5876-9-7 .
PMC
3027097 .
PMID
21232121 .
^ Turaga, Ravi Chakra; Yin, Lu; Yang, Jenny J.; Lee, Hsiauwei; Ivanov, Ivaylo; Yan, Chunli; Yang, Hua; Grossniklaus, Hans E.; Wang, Siming; Ma, Cheng; Sun, Li; Liu, Zhi-Ren (31 May 2016).
"Rational design of a protein that binds integrin αvβ3 outside the ligand binding site" . Nature Communications . 7 (1): 11675.
Bibcode :
2016NatCo...711675T .
doi :
10.1038/ncomms11675 .
PMC
4895024 .
PMID
27241473 .
^ Van Agthoven JF, Xiong JP, Alonso JL, Rui X, Adair BD, Goodman SL, Arnaout MA (April 2014).
"Structural basis for pure antagonism of integrin αVβ3 by a high-affinity form of fibronectin" . Nature Structural & Molecular Biology . 21 (4): 383–8.
doi :
10.1038/nsmb.2797 .
PMC
4012256 .
PMID
24658351 .
External links
Alpha Beta Dimers
Cytoadhesin receptor: Fibrinogen receptor: Fibronectin receptor: Leukocyte-adhesion receptor: Very late antigen receptor: Vitronectin receptor: